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Details on Person Signal transducer and activator of transcription 1 alpha/bet...

Class:IdSummation:9005434
_displayNameSignal transducer and activator of transcription 1 alpha/bet...
_timestamp2017-07-04 12:30:18
created[InstanceEdit:9005452] Duenas, Corina, 2017-05-09
literatureReference[LiteratureReference:8987116] Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
[LiteratureReference:9009139] The cationic cytokine IL-26 differentially modulates virus infection in culture
[LiteratureReference:6783812] Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009247] Duenas, Corina, 2017-06-16
[InstanceEdit:9009474] Duenas, Corina, 2017-06-19
[InstanceEdit:9009675] Duenas, Corina, 2017-06-22
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9010942] Duenas, Corina, 2017-06-28
[InstanceEdit:9011519] Jupe, Steve, 2017-07-03
[InstanceEdit:9011696] Duenas, Corina, 2017-07-04
textSignal transducer and activator of transcription 1 alpha/beta (STAT1) or Signal transducer and activator of transcription 3 (STAT3) are believed to be phosphorylated by the Interleukin 26 (IL26) receptor complex,which consists of IL26, Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2), Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) (Sheikh et al. 2004), STAT1 and STAT3.
This is a black box event since there is no direct evidence that STAT1 or STAT3 bind the receptor complex before being phosphorylated, but this can be inferred from the signaling mechanism of other related interleukin receptors such as IL10 (Weber-Nordt et al. 1996, Braum et al. 2013).
(summation)[BlackBoxEvent:8987255] IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 [Homo sapiens]
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No pathways have been reviewed or authored by Signal transducer and activator of transcription 1 alpha/bet... (9005434)
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