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Details on Person Phosphorylated Signal transducer and activator of transcript...

Class:IdSummation:9005428
_displayNamePhosphorylated Signal transducer and activator of transcript...
_timestamp2024-02-26 21:17:50
created[InstanceEdit:9005452] Duenas, Corina, 2017-05-09
literatureReference[LiteratureReference:6784788] Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
[LiteratureReference:8987116] Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
[LiteratureReference:9009139] The cationic cytokine IL-26 differentially modulates virus infection in culture
[LiteratureReference:9009241] Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009474] Duenas, Corina, 2017-06-19
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9010942] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011693] Duenas, Corina, 2017-07-04
[InstanceEdit:9863023] Matthews, Lisa, 2024-02-26
textPhosphorylated Signal transducer and activator of transcription 3 (STAT3) dissociates from the Interleukin-22 (IL22) receptor complex, which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha 1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine protein-kinase TYK2 (TYK2) and Tyrosine protein phosphatase non receptor type 11 (PTPN11 or SHP2) and STAT3. This is a black-box event because dissociation is inferred from other interleukin signaling cascades e.g. Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006) where dissociation occurs before STAT dimerization and translocation to the nucleus.
(summation)[BlackBoxEvent:8987236] p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 [Homo sapiens]
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