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Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:IdSummation:9005404
_displayNameSignal transducer and activator of transcription 3 (STAT3) i...
_timestamp2017-07-04 12:29:54
created[InstanceEdit:9005452] Duenas, Corina, 2017-05-09
literatureReference[LiteratureReference:8987139] STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
[LiteratureReference:8986981] Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation
[LiteratureReference:9011025] Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
[LiteratureReference:9005462] Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10
[LiteratureReference:8987116] Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
[LiteratureReference:8950266] New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009222] Duenas, Corina, 2017-06-16
[InstanceEdit:9009474] Duenas, Corina, 2017-06-19
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9010942] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011695] Duenas, Corina, 2017-07-04
textSignal transducer and activator of transcription 3 (STAT3) is phosphorylated by the Interleukin-22 (IL22) receptor complex (Lejeune et al. 2002, Dumoutier et al. 2009, Lindemanns et al. 2015), which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2) and STAT3 (Meng et al. 2010, Sestito et al. 2011).
(summation)[Reaction:8987070] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 [Homo sapiens]
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