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Details on Person Signal transducer and activator of transcription 3 (STAT3) d...

Class:IdSummation:9005398
_displayNameSignal transducer and activator of transcription 3 (STAT3) d...
_timestamp2017-05-19 10:42:06
created[InstanceEdit:9005452] Duenas, Corina, 2017-05-09
literatureReference[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
textSignal transducer and activator of transcription 3 (STAT3) dimerizes after dissociation from Interleukin-24 (IL24) activated receptor complex. This activated receptor complex is formed by IL24 ligand, Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2002). This is a black box event because there is not evidence this dimerization occurs after Interleukin-24 stimulus but it happens in several other Interleukin signaling cascades before traslocation to the nucleous.
(summation)[BlackBoxEvent:8987098] p-STAT3 dimerizes [Homo sapiens]
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