Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Interleukin-20 (IL20) binds a heterodimeric receptor complex...

Class:IdSummation:9005346
_displayNameInterleukin-20 (IL20) binds a heterodimeric receptor complex...
_timestamp2017-07-04 11:47:00
created[InstanceEdit:9005318] Duenas, Corina, 2017-05-08
literatureReference[LiteratureReference:8854666] Interleukin 20: discovery, receptor identification, and role in epidermal function
[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
[LiteratureReference:8854681] Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines
[LiteratureReference:8854646] The IL-20 subfamily of cytokines--from host defence to tissue homeostasis
[LiteratureReference:9009118] IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice
modified[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009474] Duenas, Corina, 2017-06-19
[InstanceEdit:9009672] Duenas, Corina, 2017-06-21
[InstanceEdit:9009675] Duenas, Corina, 2017-06-22
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011680] Jupe, Steve, 2017-07-04
textInterleukin-20 (IL20) binds a heterodimeric receptor complex that consists of Interleukin-20 receptor subunit alpha (IL20RA), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). Interleukin-20 receptor A (IL20RA) and Interleukin-20 receptor B (IL20RB) form a receptor complex for Interleukin-20 (IL20), Interleukin-19 (IL19) and Interleukin-24 (IL24) (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). IL20 can also bind a receptor complex that consists of Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Kolumam et al. 2017). As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain black box event.
(summation)[BlackBoxEvent:8987015] IL20 binds IL20RA:JAK1:IL20RB [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Interleukin-20 (IL20) binds a heterodimeric receptor complex... (9005346)
Follow Reactome