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Details on Person Interleukin-24 (IL24) binds a receptor complex containing In...

Class:IdSummation:9005328
_displayNameInterleukin-24 (IL24) binds a receptor complex containing In...
_timestamp2017-07-05 08:03:32
created[InstanceEdit:9005318] Duenas, Corina, 2017-05-08
literatureReference[LiteratureReference:9005345] Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease
[LiteratureReference:8854681] Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines
[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
[LiteratureReference:8987142] Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009672] Duenas, Corina, 2017-06-21
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011680] Jupe, Steve, 2017-07-04
[InstanceEdit:9011709] Jupe, Steve, 2017-07-05
textInterleukin-24 (IL24) binds a receptor complex containing Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) (Andoh et al. 2009, Logsdon et al. 2012) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish Novak et al.1998). Furthermore IL24 can also bind Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Wang et al. 2002) to form a ligand receptor complex.
As it is not clear whether the receptor complex can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.
(summation)[BlackBoxEvent:8986972] IL24 binds IL20RA:JAK1:IL20RB [Homo sapiens]
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