Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Phosphorylated Signal transducer and activator of transcript...

Class:IdSummation:9005326
_displayNamePhosphorylated Signal transducer and activator of transcript...
_timestamp2017-07-04 13:18:25
created[InstanceEdit:9005318] Duenas, Corina, 2017-05-08
literatureReference[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
[LiteratureReference:6784788] Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
[LiteratureReference:9010846] Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms
modified[InstanceEdit:9005489] Duenas, Corina, 2017-05-09
[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009247] Duenas, Corina, 2017-06-16
[InstanceEdit:9009474] Duenas, Corina, 2017-06-19
[InstanceEdit:9009672] Duenas, Corina, 2017-06-21
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011482] Duenas, Corina, 2017-06-30
[InstanceEdit:9011702] Duenas, Corina, 2017-07-04
textPhosphorylated Signal transducer and activator of transcription 3 (STAT3) is believed to dimerize after it dissociates from the Interleukin-24 (IL24) receptor complex.
This is a black box event because dimerization is inferred from STAT3 dimerization in response to interleukin-10 (Niemand et al. 2003) and the observed translocation of STAT3 to the nucleus in response to IL24 (Parrish-Novak et al. 2002). In several other cytokine signalling cascades a phosphorylated dimer is necessary for binding to DNA and gene transcription (Park et al. 2000).
(summation)[BlackBoxEvent:8987214] p-STAT3 dimerizes [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Phosphorylated Signal transducer and activator of transcript... (9005326)
Follow Reactome