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Details on Person IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

Class:Id	BlackBoxEvent:8987202
_displayName	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
_doRelease	TRUE
_timestamp	2017-11-15 09:03:53
authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
catalystActivity	[CatalystActivity:9005789] transmembrane receptor protein tyrosine kinase activity of IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
input	[Complex:448637] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8987062] A role for IFN-lambda1 in multiple myeloma B cell growth [LiteratureReference:8987128] Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ).
modified	[InstanceEdit:9005492] Duenas, Corina, 2017-05-09 [InstanceEdit:9005810] Duenas, Corina, 2017-05-10 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9015130] Duenas, Corina, 2017-08-08 [InstanceEdit:9016466] Duenas, Corina, 2017-08-14 [InstanceEdit:9028447] Jupe, Steve, 2017-11-07 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 JAK1 and TYK2 are phosphorylated by IFNL1:IFNLR1:JAK1:IL10RB:TYK2 receptor complex JAK1 and tyk2 are phosphorylated after il29-il29 receptor interaction
output	[Complex:8987259] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 [Homo sapiens] [Reaction:8987120] JAK1 binds IFNLR1 [Homo sapiens] [Reaction:8987223] IL10RB binds TYK2 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8987283] R-HSA-8987202.2
summation	[Summation:9005406] Tyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosin...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)	[Reaction:8987040] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 [Homo sapiens]
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No pathways have been reviewed or authored by IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (8987202)