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Details on Person IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

Class:Id	Reaction:8987132
_displayName	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
_doRelease	TRUE
_timestamp	2017-11-15 09:06:15
authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
input	[EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens] [Complex:8987001] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8986981] Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation
modified	[InstanceEdit:9006768] Duenas, Corina, 2017-05-19 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9015130] Duenas, Corina, 2017-08-08 [InstanceEdit:9016466] Duenas, Corina, 2017-08-14 [InstanceEdit:9028447] Jupe, Steve, 2017-11-07 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 PTPN11 binds to IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 activated receptor complex PTPN11 binds to IL22 receptor complex Shp2 is recruited to the tyrosine phosphorylated IL-22R1
output	[Complex:8987108] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8986995] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA [Homo sapiens] [BlackBoxEvent:8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8987398] R-HSA-8987132.2
summation	[Summation:8987262] Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, S...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8987014] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 [Homo sapiens]
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No pathways have been reviewed or authored by IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (8987132)