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Details on Person IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1

Class:Id	BlackBoxEvent:8987105
_displayName	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
_doRelease	TRUE
_timestamp	2017-11-15 09:04:18
authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
input	[DefinedSet:448648] IFNL2,IFNL3 [extracellular region] [Homo sapiens] [Complex:6784360] IL10RB:TYK2 [plasma membrane] [Homo sapiens] [Complex:8987216] IFNLR1:JAK1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8987128] Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ). [LiteratureReference:9011064] Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
modified	[InstanceEdit:9005492] Duenas, Corina, 2017-05-09 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9011706] Jupe, Steve, 2017-07-04 [InstanceEdit:9015130] Duenas, Corina, 2017-08-08 [InstanceEdit:9016466] Duenas, Corina, 2017-08-14 [InstanceEdit:9028447] Jupe, Steve, 2017-11-07 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 IFNL2,IFNL3 binds IL10RB:TYK2 and IFNLR1:JAK1 receptor complex IL28 binds to IL28 receptor complex IFNL2, INFL3 binds IFNLR1:IL10RB receptor complex
output	[Complex:8987146] IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8987120] JAK1 binds IFNLR1 [Homo sapiens] [Reaction:8987223] IL10RB binds TYK2 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8987391] R-HSA-8987105.2
summation	[Summation:8987260] Interferon lambda-1 (IFNL1) binds Interleukin-10 receptor su...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
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No pathways have been reviewed or authored by IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (8987105)