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Details on Person IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

Class:Id	BlackBoxEvent:8987096
_displayName	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
_doRelease	TRUE
_timestamp	2017-11-15 09:07:05
authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
catalystActivity	[CatalystActivity:9005803] transmembrane receptor protein tyrosine kinase activity of IL24:IL22RA1:p-JAK1:IL20RB:STAT3 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
input	[Complex:8987189] IL24:IL22RA1:p-JAK1:IL20RB:STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions [LiteratureReference:8987142] Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 [LiteratureReference:448707] Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types
modified	[InstanceEdit:9005492] Duenas, Corina, 2017-05-09 [InstanceEdit:9005810] Duenas, Corina, 2017-05-10 [InstanceEdit:9006768] Duenas, Corina, 2017-05-19 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9010848] Duenas, Corina, 2017-06-28 [InstanceEdit:9015130] Duenas, Corina, 2017-08-08 [InstanceEdit:9016466] Duenas, Corina, 2017-08-14 [InstanceEdit:9028447] Jupe, Steve, 2017-11-07 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 stat3 is phosphorylated by il22r il20rb receptor activated complex
output	[Complex:8987074] IL24:IL22RA1:p-JAK1:IL20RB:p-STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:8987063] IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 [Homo sapiens] [BlackBoxEvent:8987012] IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8987285] R-HSA-8987096.2
summation	[Summation:9005422] Signal transducer and activator of transcription 3 (STAT3) i...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8987161] p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 [Homo sapiens]
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No pathways have been reviewed or authored by IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (8987096)