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Details on Person IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1

Class:Id	BlackBoxEvent:8987084
_displayName	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1
_doRelease	TRUE
_timestamp	2017-11-15 09:04:37
authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
catalystActivity	[CatalystActivity:9005793] transmembrane receptor protein tyrosine kinase activity of IL19:IL20RA:JAK1:IL20RB [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
input	[Complex:448743] IL19:IL20RA:JAK1:IL20RB [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9005345] Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease [LiteratureReference:448707] Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types [LiteratureReference:8987142] Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
modified	[InstanceEdit:9005810] Duenas, Corina, 2017-05-10 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9009670] Duenas, Corina, 2017-06-21 [InstanceEdit:9011680] Jupe, Steve, 2017-07-04 [InstanceEdit:9015130] Duenas, Corina, 2017-08-08 [InstanceEdit:9016466] Duenas, Corina, 2017-08-14 [InstanceEdit:9028447] Jupe, Steve, 2017-11-07 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 JAK1 is phosphorylated by IL19:IL20RA:JAK1:IL20RB receptor complex JAK1 is phosphorylated after IL19:IL19 receptor interaction
output	[Complex:8987264] IL19:IL20RA:p-JAK1:IL20RB [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:448728] IL19 binds IL20RA:JAK1:IL20RB [Homo sapiens] [BlackBoxEvent:448744] IL20RA binds IL20RB [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8987373] R-HSA-8987084.2
summation	[Summation:8987060] Tyrosine-protein kinase JAK1 (JAK1) is believed to be phosph...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8982165] IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 [Homo sapiens]
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