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Details on Person IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

Class:Id	Reaction:8987070
_displayName	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
_doRelease	TRUE
_timestamp	2018-11-10 17:28:18
authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
catalystActivity	[CatalystActivity:9005794] transmembrane receptor protein tyrosine kinase activity of IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
input	[Complex:8987032] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8987139] STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
modified	[InstanceEdit:9005492] Duenas, Corina, 2017-05-09 [InstanceEdit:9005810] Duenas, Corina, 2017-05-10 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 [InstanceEdit:9015130] Duenas, Corina, 2017-08-08 [InstanceEdit:9016466] Duenas, Corina, 2017-08-14 [InstanceEdit:9028447] Jupe, Steve, 2017-11-07 [InstanceEdit:9029253] Jupe, Steve, 2017-11-15 [InstanceEdit:9628681] D'Eustachio, Peter, 2018-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 STAT3 is phosphorylated by IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 activated receptor complex STAT3 is phosphorylated by the IL22 activated receptor complex
output	[Complex:8987122] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:8987014] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 [Homo sapiens] [Reaction:8987132] IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8987382] R-HSA-8987070.3
summation	[Summation:9005404] Signal transducer and activator of transcription 3 (STAT3) i...
(hasEvent)	[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8987236] p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 [Homo sapiens]
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No pathways have been reviewed or authored by IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (8987070)