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Details on Person IL24 binds IL20RA:JAK1:IL20RB

Class:IdBlackBoxEvent:8986972
_displayNameIL24 binds IL20RA:JAK1:IL20RB
_doReleaseTRUE
_timestamp2017-11-15 09:06:32
authored[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
edited[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
input[Complex:448724] IL20RA:JAK1:IL20RB [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:448438] IL24 [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
[LiteratureReference:8854681] Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines
[LiteratureReference:8987142] Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
modified[InstanceEdit:9005363] Duenas, Corina, 2017-05-08
[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9011709] Jupe, Steve, 2017-07-05
[InstanceEdit:9029253] Jupe, Steve, 2017-11-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameIL24 binds IL20RA:JAK1:IL20RB
IL24 binds to IL20RA:JAK1:IL20RB receptor complex
IL20RA:IL20RB binds IL24
output[Complex:8987038] IL24:IL20RA:JAK1:IL20RB [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-03-23
reviewed[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8987361] R-HSA-8986972.4
summation[Summation:9005328] Interleukin-24 (IL24) binds a receptor complex containing In...
(hasEvent)[Pathway:8854691] Interleukin-20 family signaling [Homo sapiens]
(precedingEvent)[Reaction:8987129] JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780674] Update Tracker - [BlackBoxEvent:8986972] IL24 binds IL20RA:JAK1:IL20RB - v62:[modifyText]
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