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Details on Person MECP2 binds the NCoR/SMRT complex
Class:Id Reaction:8986939
_displayName MECP2 binds the NCoR/SMRT complex
_doRelease TRUE
_timestamp 2018-08-09 13:46:09
authored [InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:8986945] Orlic-Milacic, Marija, 2017-05-05
edited [InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
inferredFrom
input [CandidateSet:9005549] MECP2 [nucleoplasm] [Homo sapiens] [DefinedSet:9005706] NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:8986952] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR [LiteratureReference:9005556] Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor
modified [InstanceEdit:8986970] Orlic-Milacic, Marija, 2017-05-05 [InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9005676] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9005709] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9005751] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9608108] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608115] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608122] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608281] Orlic-Milacic, Marija, 2018-05-11 [InstanceEdit:9615853] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615854] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615857] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615861] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615974] Orlic-Milacic, Marija, 2018-08-09 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name MECP2 binds the NCoR/SMRT complex
output [Complex:9005564] MECP2:NCoR/SMRT complex [nucleoplasm] [Homo sapiens]
regulatedBy [NegativeRegulation:9005545] Negative regulation by 'Active PRKACA,CaMK IV [nucleoplasm]'
regulationReference [RegulationReference:9641774] Negative regulation by 'Active PRKACA,CaMK IV [nucleoplasm]' Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
releaseDate 2018-09-12
reviewed [InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:8986947] R-HSA-8986939.3
summation [Summation:8986941] MECP2 binds the nuclear receptor co-repressor complex (NCoR/...
(hasEvent) [Pathway:9022692] Regulation of MECP2 expression and activity [Homo sapiens]
(normalReaction) [FailedReaction:9005585] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex [Homo sapiens] [FailedReaction:9005752] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex [Homo sapiens]
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