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Details on Person MECP2 is phosphorylated at T308

Class:IdReaction:8986937
_displayNameMECP2 is phosphorylated at T308
_doReleaseTRUE
_timestamp2018-08-09 13:48:21
authored[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
catalystActivity[CatalystActivity:9005554] calcium,diacylglycerol-dependent serine/threonine kinase activity of Active PRKACA,CaMK IV [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643443] calcium-dependent protein kinase activity of Active PRKACA,CaMK IV [nucleoplasm] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:8986945] Orlic-Milacic, Marija, 2017-05-05
edited[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
inferredFrom
input[CandidateSet:9005549] MECP2 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:8986952] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
modified[InstanceEdit:8986970] Orlic-Milacic, Marija, 2017-05-05
[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
[InstanceEdit:9005859] Orlic-Milacic, Marija, 2017-05-10
[InstanceEdit:9608108] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608115] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608122] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608281] Orlic-Milacic, Marija, 2018-05-11
[InstanceEdit:9615853] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615854] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615857] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615861] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615976] Orlic-Milacic, Marija, 2018-08-09
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMECP2 is phosphorylated at T308
output[CandidateSet:9005562] p-T308-MECP2 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
releaseDate2018-09-12
reviewed[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07
[InstanceEdit:9608114] Christodoulou, John, 2018-08-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8986948] R-HSA-8986937.3
summation[Summation:8986938] Calcium-dependent protein kinases, PKA and CaMK IV, activate...
(hasEvent)[Pathway:9022692] Regulation of MECP2 expression and activity [Homo sapiens]
(normalReaction)[FailedReaction:9005561] Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 [Homo sapiens]
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