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Details on Person Activated STAT complexes induced by Interleukin-9 (IL9) were...

Class:IdSummation:8986460
_displayNameActivated STAT complexes induced by Interleukin-9 (IL9) were...
_timestamp2017-04-27 12:11:47
created[InstanceEdit:8986463] Duenas, Corina, 2017-04-27
literatureReference[LiteratureReference:8985894] A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9
textActivated STAT complexes induced by Interleukin-9 (IL9) were found to contain Signal transducer and activator of transcription 1-alpha/beta (STAT1), Signal transducer and activator of transcription 3 (STAT3), and Signal transducer and activator of transcription 5A or 5B (STAT5A or STAT5B) transcription factors. STAT1:STAT3 heterodimer, and 2xp-STAT1 or 2x(STAT5A,STAT5B) homodimers binds to DNA. Interleukin-9 (IL9) has shown to activate STAT by mean of using a 32P-labeled oligonucleotide, a motif which is known to avidly bind STAT factors. Wild-type BW5147 cells were treated or not with mouse IL9. IL9-induces DNA-binding complex , and this reaction can be selectively inhibited by a cold competitor excess (data not shown) (Demoulin et al. 1996).
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