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Details on Person CELA enzymes (Chymotrysin-like ELAstases) are a family of st...

Class:IdSummation:8985670
_displayNameCELA enzymes (Chymotrysin-like ELAstases) are a family of st...
_timestamp2017-04-18 19:34:01
created[InstanceEdit:8985668] D'Eustachio, Peter, 2017-04-18
modified[InstanceEdit:8985680] D'Eustachio, Peter, 2017-04-18
textCELA enzymes (Chymotrysin-like ELAstases) are a family of structurally similar serine endopeptidases members of which are involved in inflammatory processes, keratinization, and digestion of dietary proteins. Here the roles of four family members, CELA2A, 2B, 3A, and 3B, in digestion are annotated. All four proteins are synthesized in the exocrine pancreas as proenzymes and secreted into the lumen of the small intestine where they are activated by trypsin cleavage.

While elastase enzymes by definition catalyze the hydrolysis of peptide bonds in elastin, notably ones between glycine residues or between glycine and alanine, the four members of the CELA family of pancreatic enzymes have much broader substrate specificities (de Oliveira & Salgado 2013) and only one, CELA2A, has been shown to digest elastin itself in assays in vitro with purified enzymes (Szepessy & Sahin-Toth 2006).

(summation)[Pathway:8985532] CELA protease activation and action on dietary protein [Homo sapiens]
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