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Details on Person MYO9B inactivates RHOA

Class:IdReaction:8985594
_displayNameMYO9B inactivates RHOA
_doReleaseTRUE
_timestamp2017-08-09 19:49:09
authored[InstanceEdit:9010186] Orlic-Milacic, Marija, 2017-06-26
catalystActivity[CatalystActivity:8985587] GTPase activator activity of MYO9B [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:8985582] Orlic-Milacic, Marija, 2017-04-18
edited[InstanceEdit:9010186] Orlic-Milacic, Marija, 2017-06-26
input[Complex:5665993] RHOA:GTP [plasma membrane] [Homo sapiens]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:8985599] Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression
[LiteratureReference:8985683] Human myosin-IXb is a mechanochemically active motor and a GAP for rho
[LiteratureReference:8985695] Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri
modified[InstanceEdit:8985609] Orlic-Milacic, Marija, 2017-04-18
[InstanceEdit:8985700] Orlic-Milacic, Marija, 2017-04-18
[InstanceEdit:8985704] Orlic-Milacic, Marija, 2017-04-18
[InstanceEdit:9014258] Orlic-Milacic, Marija, 2017-07-27
[InstanceEdit:9014895] Orlic-Milacic, Marija, 2017-08-04
[InstanceEdit:9014897] Orlic-Milacic, Marija, 2017-08-04
[InstanceEdit:9015330] Orlic-Milacic, Marija, 2017-08-09
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMYO9B inactivates RHOA
output[Complex:8964174] RHOA:GDP [plasma membrane] [Homo sapiens]
[SimpleEntity:29372] Pi [cytosol]
regulatedBy[NegativeRegulation:8985589] Negative regulation by 'SLIT2:ROBO1:MYO9B [plasma membrane]'
regulationReference[RegulationReference:9642400] Negative regulation by 'SLIT2:ROBO1:MYO9B [plasma membrane]' Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression
releaseDate2017-09-12
reviewed[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8985601] R-HSA-8985594.4
summation[Summation:8985608] MYO9B (MYR5) is a RHO GAP protein that stimulates RHOA GTPas...
(hasEvent)[Pathway:8985586] SLIT2:ROBO1 increases RHOA activity [Homo sapiens]
[Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
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No pathways have been reviewed or authored by MYO9B inactivates RHOA (8985594)