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Details on Person CELA2A hydrolyzes dietary proteins

Class:Id	Reaction:8985533
_displayName	CELA2A hydrolyzes dietary proteins
_doRelease	FALSE
_timestamp	2017-04-18 19:33:47
catalystActivity	[CatalystActivity:8849620] serine-type endopeptidase activity of CELA2A [extracellular region]
catalystActivityReference	[CatalystActivityReference:9644015] serine-type endopeptidase activity of CELA2A [extracellular region] Purification and characterization of two human pancreatic elastases
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8985521] D'Eustachio, Peter, 2017-04-17
goBiologicalProcess	[GO_BiologicalProcess:161012] protein digestion
input	[OtherEntity:8984753] dietary protein [extracellular region] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8985511] Substrate specificity of human pancreatic elastase 2 [LiteratureReference:8849622] Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2 [LiteratureReference:8985540] Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans
modified	[InstanceEdit:8985559] D'Eustachio, Peter, 2017-04-17 [InstanceEdit:8985668] D'Eustachio, Peter, 2017-04-18 [InstanceEdit:9643047] Wu, G, 2019-04-04
name	CELA2A hydrolyzes dietary proteins
output	[SimpleEntity:8984770] polypeptide [extracellular region] [SimpleEntity:8984770] polypeptide [extracellular region]
precedingEvent	[Reaction:8985530] PRSS2 activates proCELA2A [Homo sapiens] [Reaction:8985864] Enteropeptidase TMPRSS15 activates trypsin-2 (PRSS2) [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8985541] R-HSA-8985533.1
summation	[Summation:8985667] In the lumen of the small intestine, CELA2A (chymotrypsin-li...
(hasEvent)	[Pathway:8985532] CELA protease activation and action on dietary protein [Homo sapiens]
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No pathways have been reviewed or authored by CELA2A hydrolyzes dietary proteins (8985533)