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Details on Person PRSS2 activates proCELA2A

Class:IdReaction:8985530
_displayNamePRSS2 activates proCELA2A
_doReleaseFALSE
_timestamp2017-04-26 22:06:05
catalystActivity[CatalystActivity:8985516] serine-type endopeptidase activity of PRSS2(24-247) [extracellular region]
catalystActivityReference[CatalystActivityReference:9644023] serine-type endopeptidase activity of PRSS2(24-247) [extracellular region] The two human trypsinogens. Inhibition spectra of the two human trypsins derived from their purified zymogens
compartment[Compartment:984] extracellular region
created[InstanceEdit:8985521] D'Eustachio, Peter, 2017-04-17
goBiologicalProcess[GO_BiologicalProcess:172710] zymogen activation
input[EntityWithAccessionedSequence:8849859] proCELA2A [extracellular region] [Homo sapiens]
[SimpleEntity:109276] H2O [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:8849622] Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2
[LiteratureReference:8985540] Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans
modified[InstanceEdit:8985559] D'Eustachio, Peter, 2017-04-17
[InstanceEdit:8985668] D'Eustachio, Peter, 2017-04-18
[InstanceEdit:8986422] D'Eustachio, Peter, 2017-04-26
[InstanceEdit:9643047] Wu, G, 2019-04-04
namePRSS2 activates proCELA2A
output[EntityWithAccessionedSequence:8849616] CELA2A [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:8849856] CELA2A propeptide [extracellular region] [Homo sapiens]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8985553] R-HSA-8985530.1
summation[Summation:8985669] Extracellular PRSS2 (trypsin-2; anionic trypsin) catalyzes t...
(hasEvent)[Pathway:8985532] CELA protease activation and action on dietary protein [Homo sapiens]
(precedingEvent)[Reaction:8985533] CELA2A hydrolyzes dietary proteins [Homo sapiens]
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No pathways have been reviewed or authored by PRSS2 activates proCELA2A (8985530)