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Details on Person In mouse, binding of the transcriptional repressor Nkx3-2 (B...

Class:IdSummation:8985325
_displayNameIn mouse, binding of the transcriptional repressor Nkx3-2 (B...
_timestamp2017-08-14 14:11:09
created[InstanceEdit:8985326] Orlic-Milacic, Marija, 2017-04-13
literatureReference[LiteratureReference:8985294] Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
[LiteratureReference:8985304] Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation
[LiteratureReference:9007714] Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter
[LiteratureReference:9007782] The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
[LiteratureReference:9007804] Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme
[LiteratureReference:9007794] Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis
modified[InstanceEdit:9007746] Orlic-Milacic, Marija, 2017-06-02
[InstanceEdit:9007775] Orlic-Milacic, Marija, 2017-06-02
[InstanceEdit:9007809] Orlic-Milacic, Marija, 2017-06-05
[InstanceEdit:9008384] Orlic-Milacic, Marija, 2017-06-08
[InstanceEdit:9009634] Orlic-Milacic, Marija, 2017-06-21
[InstanceEdit:9009774] Orlic-Milacic, Marija, 2017-06-22
[InstanceEdit:9016499] Orlic-Milacic, Marija, 2017-08-14
textIn mouse, binding of the transcriptional repressor Nkx3-2 (Bapx1) to the distal (P1) Runx2 gene promoter represses Runx2 transcription (Lengner et al. 2005, Provot et al. 2006). Runx2-P1 isoform can repress its own transcription by binding to evolutionarily conserved Runx2 response elements in the distal P1 promoter (Drissi et al. 2000). Binding of the transcription factor Dlx5, activated by Bmp2 signaling, to the P1 promoter of Runx2 activates Runx2 transcription. Msx2 can antagonize Dlx5 by binding to Dlx5 binding sites in the Runx2 promoter and repressing Runx2 transcription (Lee et al. 2005). Dlx6 is suggested to act redundantly with Dlx5 in the activation or Runx2 expression (Robledo et al. 2002, Holleville et al. 2007, Barron et al. 2011).
(summation)[BlackBoxEvent:8985328] Runx2 gene transcription is repressed by Nkx3-2 and Msx2, and activated by Dlx5,(Dlx6) [Mus musculus]
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