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Details on Person ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase...

Class:Id	Summation:8985200
_displayName	ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase...
_timestamp	2026-04-11 13:06:44
created	[InstanceEdit:8985204] Shamovsky, Veronica, 2017-04-12
literatureReference	[LiteratureReference:5223310] RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells [LiteratureReference:8985203] Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway [LiteratureReference:5223316] RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells [LiteratureReference:8985208] The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors [LiteratureReference:8985425] The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly [LiteratureReference:8985423] The iron-sulphur protein RNase L inhibitor functions in translation termination [LiteratureReference:5223324] The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells [LiteratureReference:8985419] Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro [LiteratureReference:8985427] HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand [LiteratureReference:8985428] siRNA‑induced ABCE1 silencing inhibits proliferation and invasion of breast cancer cells
modified	[InstanceEdit:8985433] Shamovsky, Veronica, 2017-04-14 [InstanceEdit:9015149] Shamovsky, Veronica, 2017-08-08 [InstanceEdit:9614492] Shamovsky, Veronica, 2018-07-27 [InstanceEdit:9987270] Shamovsky, Veronica, 2026-04-11
text	ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) is a member of the ATP-binding cassette transporters which express in the cytoplasm and the nuclear membrane. ABCE1 is induced during viral infections (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). ABCE1 (RLI) was shown to associate with RNase L inhibiting the endoribonuclease activity of RNase L, thus antagonizing the anti-viral effect of the IFN-regulated 2'-5' oligoadenylate/RNase L pathway (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). Furthermore, overexpression or knockdown of ABCE1 (RLI) has inhibitory or promoting effects on the binding of RNase L to 2'-5' oligoadenylates, rRNA cleavage, destabilization of mitochondrial mRNA, antiviral activity, and antitumor activity (Martinand C et al. 1998, 1999; Le Roy F et al. 2001; Malathi K et al. 2004; Huang B et al. 2014; Tian Y et al. 2016). Aside from its role as an RNase-L inhibitor, ABCE1 is believed to be involved in translation termination and ribosome recycling (Dong J et al. 2004; Chen ZQ et al. 2006; Khoshnevis S et al. 2010).
(summation)	[Reaction:8985201] ABCE1 binds RNASEL [Homo sapiens]
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