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Details on Person Pepsins (pepsin-A3, A4, and A5, encoded by PGA3, 4, and 5 re...
| Class:Id | Summation:8985186 |
|---|---|
| _displayName | Pepsins (pepsin-A3, A4, and A5, encoded by PGA3, 4, and 5 re... |
| _timestamp | 2017-04-11 21:06:20 |
| created | [InstanceEdit:8985184] D'Eustachio, Peter, 2017-04-11 |
| modified | [InstanceEdit:8985194] D'Eustachio, Peter, 2017-04-11 |
| text | Pepsins (pepsin-A3, A4, and A5, encoded by PGA3, 4, and 5 respectively) and gastricin (also known as pepsin-C, encoded by the PGC gene) are synthesized in chief cells in the gastric mucose as inactive proenzymes. Upon release from the chief cells, these proteins undergo conformational changes in the low-pH environment of the stomach that exposes their active sites, enabling autoactivation reactions in which aminoterminal propeptides are removed. The mature enzymes are stable and active at low pH and play a major role in the initial digestion of dietary protein (Athuada et al, 1989; Foltmann 1988; Fruton 1976). |
| (summation) | [Pathway:8984749] Pepsin activation and action on dietary protein [Homo sapiens] |
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No pathways have been reviewed or authored by Pepsins (pepsin-A3, A4, and A5, encoded by PGA3, 4, and 5 re... (8985186)
