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Details on Person OAS2 binds viral dsRNA

Class:Id	Reaction:8985138
_displayName	OAS2 binds viral dsRNA
_doRelease	TRUE
_timestamp	2026-04-27 15:38:25
authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8985092] Shamovsky, Veronica, 2017-04-11
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
input	[EntityWithAccessionedSequence:1015689] OAS2 [cytosol] [Homo sapiens] [Complex:8985053] hRSV A dsRNA intermediate form [cytosol] [Human respiratory syncytial virus A]
internalReviewed	[InstanceEdit:9987721] Stephan, Ralf, 2026-04-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9009997] Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells [LiteratureReference:9009992] Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase [LiteratureReference:8985083] Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase [LiteratureReference:8985044] 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells
modified	[InstanceEdit:9009996] Shamovsky, Veronica, 2017-06-23 [InstanceEdit:9012242] Shamovsky, Veronica, 2017-07-12 [InstanceEdit:9037720] Shamovsky, Veronica, 2018-02-20 [InstanceEdit:9038307] Shamovsky, Veronica, 2018-02-24 [InstanceEdit:9038502] Shamovsky, Veronica, 2018-02-28 [InstanceEdit:9615278] Shamovsky, Veronica, 2018-07-31 [InstanceEdit:9616210] Shamovsky, Veronica, 2018-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835668] Shamovsky, Veronica, 2023-05-17 [InstanceEdit:9837450] Orlic-Milacic, Marija, 2023-06-15 [InstanceEdit:9852855] Orlic-Milacic, Marija, 2023-11-07 [InstanceEdit:9986161] Shamovsky, Veronica, 2026-03-26 [InstanceEdit:9987722] Shamovsky, Veronica, 2026-04-27
name	OAS2 binds viral dsRNA
output	[Complex:8985050] OAS2:OAS2 ligand [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9837448] Formation of hRSV A dsRNA intermediate form [Homo sapiens] [BlackBoxEvent:9834736] Synthesis of antigenomic RNA of human respiratory syncytial virus [Homo sapiens] [BlackBoxEvent:9834719] Synthesis of negative sense genomic RNA of respiratory syncytial virus [Homo sapiens] [BlackBoxEvent:1015702] Expression of IFN-induced genes [Homo sapiens] [Reaction:1015699] ISGF3 binds the ISRE promoter elements in IFN-stimulated genes [Homo sapiens] [BlackBoxEvent:1031716] Expression of IFNG-stimulated genes [Homo sapiens] [Reaction:1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes [Homo sapiens]
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2018-09-12
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31 [InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8985163] R-HSA-8985138.4
summation	[Summation:9012238] The human oligoadenylate synthetase 2 (OAS2) is activated by...
(hasEvent)	[Pathway:8983711] OAS antiviral response [Homo sapiens] [Pathway:9833110] RSV-host interactions [Homo sapiens]
(precedingEvent)	[Reaction:8985097] OAS2 dimerizes [Homo sapiens]
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No pathways have been reviewed or authored by OAS2 binds viral dsRNA (8985138)