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Details on Person OAS3 produces oligoadenylates

Class:Id	Reaction:8985091
_displayName	OAS3 produces oligoadenylates
_doRelease	TRUE
_timestamp	2026-04-27 15:38:41
authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity	[CatalystActivity:8985036] 2'-5'-oligoadenylate synthetase activity of OAS3:viral dsRNA intermediates [cytosol]
catalystActivityReference	[CatalystActivityReference:9986167] 2'-5'-oligoadenylate synthetase activity of OAS3:viral dsRNA intermediates [cytosol] Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8985092] Shamovsky, Veronica, 2017-04-11
crossReference	[DatabaseIdentifier:9985898] RHEA:34407
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9987721] Stephan, Ralf, 2026-04-27
isChimeric	FALSE
literatureReference	[LiteratureReference:8985109] The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation [LiteratureReference:8985043] Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses
modified	[InstanceEdit:9012242] Shamovsky, Veronica, 2017-07-12 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9037720] Shamovsky, Veronica, 2018-02-20 [InstanceEdit:9038307] Shamovsky, Veronica, 2018-02-24 [InstanceEdit:9038502] Shamovsky, Veronica, 2018-02-28 [InstanceEdit:9615278] Shamovsky, Veronica, 2018-07-31 [InstanceEdit:9616210] Shamovsky, Veronica, 2018-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9986168] Shamovsky, Veronica, 2026-03-26 [InstanceEdit:9987265] Shamovsky, Veronica, 2026-04-11 [InstanceEdit:9987722] Shamovsky, Veronica, 2026-04-27
name	OAS3 produces oligoadenylates
output	[SimpleEntity:111294] PPi [cytosol] [Polymer:8983696] 2'-5' oligoadenylate [cytosol] [Homo sapiens] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:8985157] OAS3 binds viral dsRNA intermediates produced by (+)ssRNA virus [Homo sapiens] [BlackBoxEvent:1015702] Expression of IFN-induced genes [Homo sapiens] [BlackBoxEvent:1031716] Expression of IFNG-stimulated genes [Homo sapiens]
relatedSpecies	[Species:8983656] West Nile virus [Species:8985057] Sindbis virus [Species:3244621] Dengue virus type 2
releaseDate	2018-09-12
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8985161] R-HSA-8985091.2
summation	[Summation:8983638] 2′-5′-Oligoadenylate synthetase 3 (OAS3) is a template-indep...
(hasEvent)	[Pathway:8983711] OAS antiviral response [Homo sapiens]
(precedingEvent)	[Reaction:8985123] RNASEL binds 2'-5' oligoadenylate [Homo sapiens]
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No pathways have been reviewed or authored by OAS3 produces oligoadenylates (8985091)