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Details on Person proPGA4 (pepsin A-4 precursor) catalyzes its own hydrolysis ...
| Class:Id | Summation:8984767 |
|---|---|
| _displayName | proPGA4 (pepsin A-4 precursor) catalyzes its own hydrolysis ... |
| _timestamp | 2017-04-11 21:06:10 |
| created | [InstanceEdit:8984737] D'Eustachio, Peter, 2017-04-10 |
| modified | [InstanceEdit:8985184] D'Eustachio, Peter, 2017-04-11 |
| text | proPGA4 (pepsin A-4 precursor) catalyzes its own hydrolysis to yield PGA4 and a propeptide. In the body, the precursor protein is synthesized in gastric chief cells. As it is released into the lumen of the stomach, the low stomach pH induced a conformational change that exposes the protein's active site and the peptide bond between residues 62 and 63 of the precursor protein is cleaved to yield the mature catalytically active pepsin and a propeptide of no known function (Athuada et al. 1989; Foltmann 1988). |
| (summation) | [Reaction:8984760] Autoactivation of proPGA4 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by proPGA4 (pepsin A-4 precursor) catalyzes its own hydrolysis ... (8984767)
