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Details on Person JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

Class:Id	BlackBoxEvent:8984012
_displayName	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
_doRelease	TRUE
_timestamp	2017-08-09 08:27:31
authored	[InstanceEdit:8952430] Varusai, Thawfeek, 2016-12-15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8983984] Varusai, Thawfeek, 2017-04-03
edited	[InstanceEdit:8952430] Varusai, Thawfeek, 2016-12-15
input	[Complex:8983989] IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8984020] IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases [LiteratureReference:8949808] Interleukin-35 induces regulatory B cells that suppress autoimmune disease
modified	[InstanceEdit:8984034] Varusai, Thawfeek, 2017-04-03 [InstanceEdit:8984721] Varusai, Thawfeek, 2017-04-10 [InstanceEdit:8984884] Varusai, Thawfeek, 2017-04-11 [InstanceEdit:8985393] Varusai, Thawfeek, 2017-04-13 [InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16 [InstanceEdit:9006961] Jupe, Steve, 2017-05-24 [InstanceEdit:9011723] Varusai, Thawfeek, 2017-07-05 [InstanceEdit:9015171] Varusai, Thawfeek, 2017-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:8985392] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8984001] IL35 binds IL27RA:IL12RB2 receptor [Homo sapiens] [BlackBoxEvent:448627] Interleukin-35 translocates from the ER lumen to the extracellular region [Homo sapiens] [Reaction:8950716] IL27RA binds JAK1 [Homo sapiens] [Reaction:8950063] IL12RB2 binds JAK2 [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9011722] Singh, Kailash, 2017-07-05 [InstanceEdit:9015170] Pylayeva-Gupta, Yuliya, 2017-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8984033] R-HSA-8984012.2
summation	[Summation:8984009] Interleukin 35 (IL35) presumably signal via a complex that i...
(hasEvent)	[Pathway:8984722] Interleukin-35 Signalling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor [Homo sapiens]
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