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Details on Person IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5

Class:Id	BlackBoxEvent:8983371
_displayName	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
_doRelease	TRUE
_timestamp	2017-11-03 09:50:06
authored	[InstanceEdit:9014992] Duenas, Corina, 2017-08-07
catalystActivity	[CatalystActivity:8984979] transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643470] transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8983388] Duenas, Corina, 2017-03-23
edited	[InstanceEdit:9015191] Duenas, Corina, 2017-08-09
input	[Complex:8983118] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified	[InstanceEdit:8983909] Duenas, Corina, 2017-03-31 [InstanceEdit:8984982] Duenas, Corina, 2017-04-11 [InstanceEdit:9007193] Duenas, Corina, 2017-05-26 [InstanceEdit:9009740] Duenas, Corina, 2017-06-22 [InstanceEdit:9010003] Duenas, Corina, 2017-06-26 [InstanceEdit:9011555] Duenas, Corina, 2017-07-03 [InstanceEdit:9014998] Duenas, Corina, 2017-08-07 [InstanceEdit:9015106] Duenas, Corina, 2017-08-08 [InstanceEdit:9015193] Duenas, Corina, 2017-08-09 [InstanceEdit:9027591] Jupe, Steve, 2017-11-03 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 STAT3 is phosphorylated after IL15-IL15 receptor interaction
output	[Complex:8983137] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:8983378] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 [Homo sapiens] [BlackBoxEvent:9009700] IL2RB and IL2RG are phosphorylated [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9014997] Patidar, Manoj, 2017-08-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8983399] R-HSA-8983371.4
summation	[Summation:8983262] Signal transducer and activator of transcription 3 (STAT3) a...
(hasEvent)	[Pathway:8983432] Interleukin-15 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8983374] p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780322] Update Tracker - [BlackBoxEvent:8983371] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 - v63:[modifyText]
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No pathways have been reviewed or authored by IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (8983371)