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Details on Person Interleukin 15 (IL15) binds Interleukin 15 receptor subunit ...

Class:IdSummation:8983304
_displayNameInterleukin 15 (IL15) binds Interleukin 15 receptor subunit ...
_timestamp2017-08-07 15:15:33
created[InstanceEdit:8983295] Duenas, Corina, 2017-03-23
literatureReference[LiteratureReference:9006754] Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
[LiteratureReference:449144] Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
[LiteratureReference:449142] Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
[LiteratureReference:8983115] IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
[LiteratureReference:9014940] Identification of an interleukin-15alpha receptor-binding site on human interleukin-15
modified[InstanceEdit:8983475] Jupe, Steve, 2017-03-24
[InstanceEdit:8983912] Duenas, Corina, 2017-03-31
[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:9006767] Jupe, Steve, 2017-05-19
[InstanceEdit:9007192] Duenas, Corina, 2017-05-26
[InstanceEdit:9010003] Duenas, Corina, 2017-06-26
[InstanceEdit:9011615] Duenas, Corina, 2017-07-03
[InstanceEdit:9011675] Duenas, Corina, 2017-07-04
[InstanceEdit:9014942] Duenas, Corina, 2017-08-07
[InstanceEdit:9014988] Duenas, Corina, 2017-08-07
textInterleukin 15 (IL15) binds Interleukin 15 receptor subunit alpha (IL15RA, IL15Rα). The high affinity Interleukin 15 receptor is a heterotrimer of IL15RA, Interleukin 2 receptor subunit beta (IL2RB, IL2Rβ, IL15RB) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ). IL15RA is structurally related to the alpha subunit of the Interleukin-2 receptor and determines high affinity binding for Interleukin 15 (IL15) (Giri et al. 1994, 1995, Anderson et al. 1995, Dubois et al. 2002). More in detail, IL15RA binds specifically to IL15 with high affinity (Kd=30-100 pM), whereas IL2RA specifically binds to IL2 with a comparatively lower affinity (Kd=10-30 nM) (Bernard et al. 2004).
(summation)[Reaction:8983307] IL15 binds IL15RA [Homo sapiens]
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