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Details on Person IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1

Class:Id	BlackBoxEvent:8983300
_displayName	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
_doRelease	TRUE
_timestamp	2017-08-09 13:01:57
authored	[InstanceEdit:9014992] Duenas, Corina, 2017-08-07
catalystActivity	[CatalystActivity:8984981] transmembrane receptor protein tyrosine kinase activity of IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643756] transmembrane receptor protein tyrosine kinase activity of IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8983295] Duenas, Corina, 2017-03-23
edited	[InstanceEdit:9015191] Duenas, Corina, 2017-08-09
input	[Complex:449120] IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified	[InstanceEdit:8983475] Jupe, Steve, 2017-03-24 [InstanceEdit:8984725] Jupe, Steve, 2017-04-10 [InstanceEdit:8984982] Duenas, Corina, 2017-04-11 [InstanceEdit:9007193] Duenas, Corina, 2017-05-26 [InstanceEdit:9009740] Duenas, Corina, 2017-06-22 [InstanceEdit:9014998] Duenas, Corina, 2017-08-07 [InstanceEdit:9015106] Duenas, Corina, 2017-08-08 [InstanceEdit:9015193] Duenas, Corina, 2017-08-09 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 JAK3 is phosphorylated after IL15 stimulation
output	[Complex:8983138] IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 [Homo sapiens] [Reaction:8983307] IL15 binds IL15RA [Homo sapiens] [Reaction:451900] IL2RB binds JAK1 [Homo sapiens] [Reaction:451895] IL2RG binds JAK3 [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9014997] Patidar, Manoj, 2017-08-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8983325] R-HSA-8983300.3
summation	[Summation:8983269] Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kina...
(hasEvent)	[Pathway:8983432] Interleukin-15 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8983314] JAK1 is phosphorylated by p-JAK3 in IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3 complex [Homo sapiens] [BlackBoxEvent:9009700] IL2RB and IL2RG are phosphorylated [Homo sapiens]
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No pathways have been reviewed or authored by IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (8983300)