Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Inferred from mouse:GRB2 is recruited by phosphorylated SHC1...

Class:IdSummation:8983290
_displayNameInferred from mouse:GRB2 is recruited by phosphorylated SHC1...
_timestamp2017-10-03 13:51:17
created[InstanceEdit:8983283] Duenas, Corina, 2017-03-23
literatureReference[LiteratureReference:9009730] Signaling T-cell survival and death by IL-2 and IL-15
[LiteratureReference:8983265] The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
[LiteratureReference:443188] Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras
[LiteratureReference:9011564] A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase
[LiteratureReference:9014938] Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
modified[InstanceEdit:8983894] Duenas, Corina, 2017-03-31
[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:9007192] Duenas, Corina, 2017-05-26
[InstanceEdit:9009740] Duenas, Corina, 2017-06-22
[InstanceEdit:9009893] Duenas, Corina, 2017-06-23
[InstanceEdit:9010003] Duenas, Corina, 2017-06-26
[InstanceEdit:9011568] Duenas, Corina, 2017-07-03
[InstanceEdit:9011678] Duenas, Corina, 2017-07-04
[InstanceEdit:9014942] Duenas, Corina, 2017-08-07
[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
[InstanceEdit:9024307] Duenas, Corina, 2017-10-03
textInferred from mouse:GRB2 is recruited by phosphorylated SHC1 in the IL15 receptor complex (Zambricki et al. 2005, Gadina et al. 2000), as it is in the Interleukin-2 receptor complex (Li et al. 1994, Bennett et al. 1994).More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross-reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published).
(summation)[Reaction:8983394] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Inferred from mouse:GRB2 is recruited by phosphorylated SHC1... (8983290)
Follow Reactome