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Details on Person Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kina...

Class:IdSummation:8983269
_displayNameTyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kina...
_timestamp2017-08-07 15:30:47
created[InstanceEdit:8983267] Duenas, Corina, 2017-03-23
literatureReference[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
[LiteratureReference:9009843] IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells
modified[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:9007194] Duenas, Corina, 2017-05-26
[InstanceEdit:9009740] Duenas, Corina, 2017-06-22
[InstanceEdit:9009893] Duenas, Corina, 2017-06-23
[InstanceEdit:9010003] Duenas, Corina, 2017-06-26
[InstanceEdit:9011557] Duenas, Corina, 2017-07-03
[InstanceEdit:9011720] Jupe, Steve, 2017-07-05
[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
textTyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kinase JAK3 (JAK3) are believed to be phosphorylated after stimulation of the Interleukin-15 receptor complex by Interleukin-15 (IL15) (Johnston et al. 1995), though it has been reported that only JAK3 phosphorylation increases in response to IL15 (Krolopp et al. 2016). The Interleukin-15 receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). This is a black box event since the mechanism by which IL15 promotes JAK phosphorylation is unclear.
(summation)[BlackBoxEvent:8983300] IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 [Homo sapiens]
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