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Details on Person Signal transducer and activator of transcription 3 (STAT3) a...

Class:IdSummation:8983262
_displayNameSignal transducer and activator of transcription 3 (STAT3) a...
_timestamp2017-10-03 13:51:21
created[InstanceEdit:8983267] Duenas, Corina, 2017-03-23
literatureReference[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
[LiteratureReference:1295530] The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
[LiteratureReference:9009844] STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells
[LiteratureReference:9009857] Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells
[LiteratureReference:9009843] IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells
modified[InstanceEdit:8983896] Duenas, Corina, 2017-03-31
[InstanceEdit:9007193] Duenas, Corina, 2017-05-26
[InstanceEdit:9009740] Duenas, Corina, 2017-06-22
[InstanceEdit:9009893] Duenas, Corina, 2017-06-23
[InstanceEdit:9010003] Duenas, Corina, 2017-06-26
[InstanceEdit:9011556] Duenas, Corina, 2017-07-03
[InstanceEdit:9011568] Duenas, Corina, 2017-07-03
[InstanceEdit:9011677] Duenas, Corina, 2017-07-04
[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
[InstanceEdit:9024307] Duenas, Corina, 2017-10-03
textSignal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 5A or 5B (STAT5A,STAT5B or STAT5) are phosphorylated after Interleukin 15 (IL15) stimulation of the IL15 receptor complex (Johnston et al. 1995, Lin et al. 1995, Okada et al. 2015, Cooley et al. 2015, Krolopp et al. 2016), which consists of IL15, Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα), Interleukin 2 receptor beta subunit (IL2RB, IL2Rβ), Tyrosine protein kinase JAK1 (JAK1), Cytokine receptor common subunit gamma (IL2RG, IL2Rγ) and Tyrosine protein kinase JAK3 (JAK3).<br>Treatment of human T cells with Interleukin 15 (IL15) and Interleukin 2 (IL2) resulted in the tyrosine phosphorylation of JAK1 and JAK3. Additionally, there was a rapid induction of DNA binding complexes that contained STAT3 and STAT5, both of which were tyrosine phosphorylated (Johnston et al. 1995).This is a black-box event because it is not clear which receptor-associated kinase is responsible for STAT phosphorylation.
(summation)[BlackBoxEvent:8983371] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 [Homo sapiens]
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