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Details on Person The formation of Interleukin-15/Interleukin-15 receptor alph...

Class:IdSummation:8983260
_displayNameThe formation of Interleukin-15/Interleukin-15 receptor alph...
_timestamp2017-10-03 13:51:26
created[InstanceEdit:8983267] Duenas, Corina, 2017-03-23
literatureReference[LiteratureReference:8983115] IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
[LiteratureReference:8949834] The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
modified[InstanceEdit:8983896] Duenas, Corina, 2017-03-31
[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:9007194] Duenas, Corina, 2017-05-26
[InstanceEdit:9009740] Duenas, Corina, 2017-06-22
[InstanceEdit:9011622] Duenas, Corina, 2017-07-03
[InstanceEdit:9011625] Duenas, Corina, 2017-07-03
[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
[InstanceEdit:9014992] Duenas, Corina, 2017-08-07
[InstanceEdit:9024307] Duenas, Corina, 2017-10-03
textThe formation of Interleukin-15/Interleukin-15 receptor alpha complexes (IL15:IL15RA or IL15: IL15Rα) on cell surfaces induce a trans-endosomal recycling of IL15 leading to the persistence of surface-bound IL15 due to the constant reappearance of IL15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL15RA after IL15 withdrawal (Dubois et al. 2000). This is a black box event since the details of other potential receptors and proteins participating in this event, remain unclear. It is shown similar patterns for other interleukins (i.e: Interleukin-12, Chiaruttini et al. 2016).
(summation)[BlackBoxEvent:8983335] IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome [Homo sapiens]
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