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Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:IdSummation:8983250
_displayNameSignal transducer and activator of transcription 3 (STAT3) i...
_timestamp2017-08-07 15:30:35
created[InstanceEdit:8983249] Duenas, Corina, 2017-03-23
literatureReference[LiteratureReference:8983248] Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules
[LiteratureReference:8983258] The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
[LiteratureReference:539064] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
modified[InstanceEdit:8983896] Duenas, Corina, 2017-03-31
[InstanceEdit:8984725] Jupe, Steve, 2017-04-10
[InstanceEdit:8984982] Duenas, Corina, 2017-04-11
[InstanceEdit:9007193] Duenas, Corina, 2017-05-26
[InstanceEdit:9007330] Duenas, Corina, 2017-05-30
[InstanceEdit:9009740] Duenas, Corina, 2017-06-22
[InstanceEdit:9009893] Duenas, Corina, 2017-06-23
[InstanceEdit:9010003] Duenas, Corina, 2017-06-26
[InstanceEdit:9011556] Duenas, Corina, 2017-07-03
[InstanceEdit:9011568] Duenas, Corina, 2017-07-03
[InstanceEdit:9011677] Duenas, Corina, 2017-07-04
[InstanceEdit:9011720] Jupe, Steve, 2017-07-05
[InstanceEdit:9014942] Duenas, Corina, 2017-08-07
[InstanceEdit:9014989] Duenas, Corina, 2017-08-07
textSignal transducer and activator of transcription 3 (STAT3) is believed to bind Signal transducer and activator of transcription 5A/5B (STAT5). IL15 stimulation leads to the formation of DNA binding complexes that contain STAT3 and STAT5 (Johnston et al. 1995, Giron-Michel et al. 2003). This is a black box event because dimer formation is inferred from STAT3 and STAT5 co-occurrence in DNA binding complexes.
(summation)[BlackBoxEvent:8983373] p-Y-STAT3 binds p-STAT5 [Homo sapiens]
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