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Details on Person JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated

Class:Id	BlackBoxEvent:8983063
_displayName	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
_doRelease	TRUE
_timestamp	2017-10-20 15:27:10
authored	[InstanceEdit:9012845] Duenas, Corina, 2017-07-20
catalystActivity	[CatalystActivity:9005811] transmembrane receptor protein kinase activity of IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8983062] Duenas, Corina, 2017-03-22
edited	[InstanceEdit:9014125] Duenas, Corina, 2017-07-26
input	[Complex:449967] IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1295530] The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15 [LiteratureReference:9021110] LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors
modified	[InstanceEdit:9005813] Duenas, Corina, 2017-05-10 [InstanceEdit:9012011] Jupe, Steve, 2017-07-07 [InstanceEdit:9014123] Duenas, Corina, 2017-07-26 [InstanceEdit:9014125] Duenas, Corina, 2017-07-26 [InstanceEdit:9015191] Duenas, Corina, 2017-08-09 [InstanceEdit:9025936] Jupe, Steve, 2017-10-16 [InstanceEdit:9026564] Jupe, Steve, 2017-10-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated JAK3 is phosphorylated after IL7:IL7R binding
output	[Complex:9025934] IL7:IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:449958] IL7:IL7R:JAK1 binds IL2RG:JAK3 [Homo sapiens] [Reaction:451895] IL2RG binds JAK3 [Homo sapiens] [Reaction:449978] IL7 binds IL7R:JAK1 [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9014118] Kumar, Umesh, 2017-07-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8983097] R-HSA-8983063.3
summation	[Summation:8982880] Interleukin-7 (IL7) signaling is believed to resemble that o...
(hasEvent)	[Pathway:1266695] Interleukin-7 signaling [Homo sapiens]
(precedingEvent)	[Reaction:1295519] IL7R is phosphorylated on Y499 [Homo sapiens] [BlackBoxEvent:9020805] IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:p-JAK3 binds MSN,ERZ [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780375] Update Tracker - [BlackBoxEvent:8983063] JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated - v63:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (8983063)