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Details on Person UniProt:P70290 Mpp1
| Class:Id | ReferenceGeneProduct:89829 |
|---|---|
| _chainChangeLog | chain:1-466 added on Fri February 6 2015;chain:1-466 removed on Tue November 3 2015;initiator methionine:1 added on Tue November 3 2015;chain:2-466 added on Tue November 3 2015;initiator methionine:1 for 89829 removed on Fri Nov 03 2023;initiator methionine: for 89829 added on Fri Nov 03 2023;initiator methionine: for 89829 removed on Fri Aug 15 2025;initiator methionine:1 for 89829 added on Fri Aug 15 2025 |
| _displayName | UniProt:P70290 Mpp1 |
| _timestamp | 2025-08-15 20:59:25 |
| chain | initiator methionine:1 chain:2-466 |
| checksum | 8724DE75A717A464 |
| comment | FUNCTION Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.SUBUNIT Heterodimer with PALS1. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN (via third PDZ domain).INTERACTION Colocalizes with WHRN at stereocilium tip during hair cell development (PubMed:16829577). Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM) (PubMed:17584769). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies, and at connecting cilium (CC) (PubMed:17584769). Colocalizes with NF2 in non-myelin-forming Schwann cells (By similarity).TISSUE SPECIFICITY Abundantly expressed in the erythrocytes (at protein level).DEVELOPMENTAL STAGE During development of the retina, expression is highest in the inner, neuroblastic layer, while at later stages it is also present in the photoreceptor cell layer. Detected in the eye from 14.5 dpc onwards. Highly expressed in the liver and primitive gut, and at lower levels in the umbilical vein, the ventricular layer of the CNS and upper/lower jaw region. At 14.5 dpc and 16.5 dpc, expression in the liver and stomach is maintained. In addition, expression is present in bone structures (e.g. zygomatic bone, lower jawbone), cranial nerve ganglia [e.g. trigeminal (V) ganglion] and cochlea. The expression in the eye is seen in the neuroblastic layer. At 16.5 dpc and 18.5 dpc, a slightly higher expression is seen in the neuroblastic layer. At 16.5 dpc, strong expression in the upper part of the gut is maintained and with the onset of ossification, expression is seen in all bone structures of the body. At P7 and P90, expression in the eye is seen in the ganglion cell layer, the inner nuclear layer (INL) and photoreceptor cell layer.PTM Palmitoylated.DISRUPTION PHENOTYPE Neutrophils form multiple transient pseudopods upon chemotactic stimulation, and do not migrate efficiently in vitro.SIMILARITY Belongs to the MAGUK family. |
| description | recommendedName: 55 kDa erythrocyte membrane protein shortName: p55 alternativeName: Membrane protein, palmitoylated 1 |
| geneName | Mpp1 |
| identifier | P70290 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell membrane Cell projection Lipoprotein Membrane Palmitate Phosphoprotein Reference proteome SH3 domain |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Mpp1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | EM55_MOUSE |
| sequenceLength | 466 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9663224] Mpp1 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P70290 Mpp1 (89829)
