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Details on Person It is suggested that Protein-tyrosine kinase 2-beta (Ptk2b o...
| Class:Id | Summation:8982796 |
|---|---|
| _displayName | It is suggested that Protein-tyrosine kinase 2-beta (Ptk2b o... |
| _timestamp | 2017-04-24 13:18:31 |
| created | [InstanceEdit:8982795] Duenas, Corina, 2017-03-22 |
| literatureReference | [LiteratureReference:8982793] Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha. |
| modified | [InstanceEdit:8986247] Duenas, Corina, 2017-04-24 |
| text | It is suggested that Protein-tyrosine kinase 2-beta (Ptk2b or Pyk2) could be a Tyrosine-protein kinase JAK1(Jak1) (rather than Tyrosine-protein kinase JAK3(Jak3)) substrate because Jak1 and Ptk2b were shown to be physically associated, although the basal phosphorylation of Ptk2b (in the absence of Interleukin-7) could be the result of the activity of a different kinase. Ptk2b was found to be physically associated with Jak1 prior to Il7 stimulation and to increase its association with Interleukin-7 receptor alpha subunit (Il7r or IL-7RA) chain following Il7 stimulation. Stimulation of D1 (or normal pro-T) cells by Il7 rapidly increased tyrosine phosphorylation and enzymatic activity of Ptk2b, with kinetics slightly lagging that of Jak1 and Jak3 phosphorylation (Benbernou et al. 2000). This is a BlackBox event since there the identity of the kinase that phosphorylates Ptk2b is unknown and if becuase it is unknown if the receptor forms a complex with other subunits. |
| (summation) | [BlackBoxEvent:8983075] Ptk2b is phosphorylated [Mus musculus] |
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