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Details on Person ADRB2:GRK complex dissociates to Phosphorylated ADRB2

Class:Id	Reaction:8982641
_displayName	ADRB2:GRK complex dissociates to Phosphorylated ADRB2
_doRelease	TRUE
_timestamp	2017-07-11 09:36:37
authored	[InstanceEdit:8851799] Jupe, Steve, 2016-01-11
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21
edited	[InstanceEdit:9005907] Jupe, Steve, 2017-05-11
input	[Complex:8982648] pS-ADRB2:Catecholamine:GRK [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8851801] Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor [LiteratureReference:8852024] Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase [LiteratureReference:8852210] Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration [LiteratureReference:8852155] G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer
modified	[InstanceEdit:8982660] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9006074] Jupe, Steve, 2017-05-12 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ADRB2:GRK complex dissociates to Phosphorylated ADRB2
output	[Complex:8852152] pS-ADRB2:Catecholamine [plasma membrane] [Homo sapiens] [DefinedSet:8852026] GRK2, GRK3, GRK5, GRK6 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8851797] ADRB2 in ADRB2:GRK complex is phosphorylated [Homo sapiens] [Reaction:8982645] GRKs bind ADRB2:Catecholamine [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:8852258] Jassal, Bijay, 2016-01-15
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8982659] R-HSA-8982641.3
summation	[Summation:8982647] G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK)...
(hasEvent)	[Pathway:418555] G alpha (s) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:8852167] ADRB2:Catecholamine binds ARRB1, ARRB2 [Homo sapiens]
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