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Details on Person cGAS ligands [cytosol]

Class:Id	DefinedSet:8982071
_displayName	cGAS ligands [cytosol]
_timestamp	2017-03-15 18:39:23
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8982070] Shamovsky, Veronica, 2017-03-15
disease	[Disease:3134794] viral infectious disease [Disease:3134792] bacterial infectious disease
goCellularComponent	[Compartment:436407] host cell cytosol
hasMember	[GenomeEncodedEntity:8982066] HSV1 dsDNA [cytosol] [Human herpesvirus 1] [Complex:177535] viral DNA with 3' sticky ends [cytosol] [Human immunodeficiency virus 1] [GenomeEncodedEntity:8982063] M. tuberculosis dsDNA [cytosol] [Mycobacterium tuberculosis] [GenomeEncodedEntity:8982051] L. monocytogenes dsDNA [cytosol] [Listeria monocytogenes]
literatureReference	[LiteratureReference:8982064] Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses [LiteratureReference:3244591] Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA [LiteratureReference:8982049] A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis [LiteratureReference:8982046] The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy [LiteratureReference:8982056] Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
modified	[InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	cGAS ligands
species	[Species:164493] Human immunodeficiency virus 1 [Species:176806] Mycobacterium tuberculosis [Species:5689680] Human herpesvirus 1 [Species:8875362] Listeria monocytogenes
stableIdentifier	[StableIdentifier:8982079] R-NUL-8982071.19
(hasComponent)	[Complex:3244625] cGAS:dsDNA [cytosol] [Homo sapiens]
(input)	[Reaction:3244647] cGAS binds cytosolic DNA [Homo sapiens]
(replacementInstances)	[_Deleted:9014368] Deletion of instance: 3244637
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No pathways have been reviewed or authored by cGAS ligands [cytosol] (8982071)