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Details on Person Interleukin-34 (IL34) signals via the Colony-stimulating fac...
| Class:Id | Summation:8981678 |
|---|---|
| _displayName | Interleukin-34 (IL34) signals via the Colony-stimulating fac... |
| _timestamp | 2017-11-03 14:59:20 |
| created | [InstanceEdit:8981679] Jupe, Steve, 2017-03-13 |
| literatureReference | [LiteratureReference:8981680] Receptor-type protein-tyrosine phosphatase ΞΆ is a functional receptor for interleukin-34 |
| modified | [InstanceEdit:9011377] Jupe, Steve, 2017-06-30 [InstanceEdit:9027647] Jupe, Steve, 2017-11-03 |
| text | Interleukin-34 (IL34) signals via the Colony-stimulating factor-1 receptor (CSF1R). It can also bind Receptor-type protein-tyrosine phosphatase zeta (PTPRZ1), a cell surface chondroitin sulfate (CS) proteoglycan. PTPRZ1 is primarily expressed on neural progenitor and glial cells. IL34 selectively bound PTPRZ1 in CSF1R-deficient U251 human glioblastoma cell lysates, inhibiting proliferation, clonogenicity and motility, and promoting an increase in tyrosine phosphorylation of focal adhesion kinase 1 (PTK2) and paxillin (PXN) (Nandii et al. 2013). |
| (summation) | [Reaction:8981657] IL34 dimer binds PTPRZ1 [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin-34 (IL34) signals via the Colony-stimulating fac... (8981678)
