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Details on Person GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol

Class:Id	Reaction:8981574
_displayName	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-14 07:59:14
authored	[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
catalystActivity	[CatalystActivity:211383] D-glucose transmembrane transporter activity of GLUT2 / SLC2A2 tetramer [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643960] D-glucose transmembrane transporter activity of GLUT2 / SLC2A2 tetramer [plasma membrane] Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8981563] D'Eustachio, Peter, 2017-03-10
edited	[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
goBiologicalProcess	[GO_BiologicalProcess:6808140] D-glucose transmembrane transport
input	[SimpleEntity:70115] Glc [extracellular region]
literatureReference	[LiteratureReference:428815] A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity [LiteratureReference:189235] Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors [LiteratureReference:189220] Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome [LiteratureReference:264743] GLUT2 in pancreatic and extra-pancreatic gluco-detection (review) [LiteratureReference:189239] Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity
modified	[InstanceEdit:8981581] D'Eustachio, Peter, 2017-03-10 [InstanceEdit:9006093] D'Eustachio, Peter, 2017-05-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963472] Stephan, Ralf, 2025-08-14
name	GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol
negativePrecedingEvent	[NegativePrecedingEvent:9963456] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963440] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
output	[SimpleEntity:70113] Glc [cytosol]
releaseDate	2004-07-06
reverseReaction	[Reaction:450095] GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [Homo sapiens]
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8981578] R-HSA-8981574.4
summation	[Summation:70405] Tetrameric GLUT2, the SLC2A2 gene product, associated with t...
(hasEvent)	[Pathway:189200] Cellular hexose transport [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963436] Futile Cycle: GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol [NegativePrecedingEvent:9963479] Futile Cycle: GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol
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