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Details on Person GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

Class:Id	Reaction:8981570
_displayName	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-14 07:59:44
authored	[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
catalystActivity	[CatalystActivity:8981550] D-glucose transmembrane transporter activity of GLUT4 / SLC2A4 tetramer [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8981563] D'Eustachio, Peter, 2017-03-10
edited	[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
goBiologicalProcess	[GO_BiologicalProcess:6808140] D-glucose transmembrane transport
input	[SimpleEntity:70115] Glc [extracellular region]
literatureReference	[LiteratureReference:70143] Regulated transport of the glucose transporter GLUT4 [LiteratureReference:428777] Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects [LiteratureReference:70388] Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. [LiteratureReference:428811] Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus
modified	[InstanceEdit:8981581] D'Eustachio, Peter, 2017-03-10 [InstanceEdit:9006093] D'Eustachio, Peter, 2017-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963472] Stephan, Ralf, 2025-08-14
name	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol
negativePrecedingEvent	[NegativePrecedingEvent:9963441] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963445] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
output	[SimpleEntity:70113] Glc [cytosol]
releaseDate	2004-07-06
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8981576] R-HSA-8981570.3
summation	[Summation:8981559] Tetrameric GLUT4, the SLC2A4 gene product, associated with t...
(hasEvent)	[Pathway:189200] Cellular hexose transport [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963437] Futile Cycle: GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol [NegativePrecedingEvent:9963464] Futile Cycle: GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol
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