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Details on Person UniProt:Q15369 ELOC

Class:Id	ReferenceGeneProduct:89814
_chainChangeLog	chain:1-112 added on Fri February 6 2015
_displayName	UniProt:Q15369 ELOC
_timestamp	2026-02-20 23:05:05
chain	chain:1-112
checksum	98D88696E883538B
comment	FUNCTION SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).FUNCTION Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:21199876, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:30166453, PubMed:33268465, PubMed:38326650, PubMed:35512830, PubMed:37844242, PubMed:39039081, PubMed:40440427). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:36805027, PubMed:37844242, PubMed:38177675). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (PubMed:33268465). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (PubMed:40440427).FUNCTION (Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:18562529, PubMed:20532212, PubMed:22190037, PubMed:24225024, PubMed:24402281, PubMed:36754086). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (CUL2 or CUL5), a catalytic subunit (RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB7, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1, ZYG11B or RAB40C (PubMed:10205047, PubMed:11006129, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:17189197, PubMed:17304241, PubMed:19920177, PubMed:21980433, PubMed:23102700, PubMed:23837592, PubMed:24337577, PubMed:25505247, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:31182716, PubMed:31387940, PubMed:32513959, PubMed:33268465, PubMed:34700328, PubMed:34857742, PubMed:35486881, PubMed:37816714, PubMed:38418882, PubMed:38326650, PubMed:35512830, PubMed:37844242, PubMed:40440427). Interacts with TMF1 (PubMed:15467733). As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1 (PubMed:22510880). May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer (By similarity).SUBUNIT (Microbial infection) Interacts with HIV-1 Vif; forming an active cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex).SUBUNIT (Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.SUBUNIT (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.SUBUNIT (Microbial infection) Interacts with molluscum contagiosum virus MC132.SUBUNIT (Microbial infection) Interacts with herpes virus 8 virus protein LANA1.INTERACTION Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.PTM Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome.SIMILARITY Belongs to the SKP1 family.
description	recommendedName: Elongin-C shortName: EloC alternativeName: Elongin 15 kDa subunit alternativeName: RNA polymerase II transcription factor SIII subunit C alternativeName: SIII p15 alternativeName: Transcription elongation factor B polypeptide 1
geneName	ELOC TCEB1
identifier	Q15369
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Host-virus interaction Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Ubl conjugation pathway
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	ELOC
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9001136] ENSEMBL:ENSG00000154582 ELOC [Homo sapiens]
secondaryIdentifier	ELOC_HUMAN E5RGD9 Q567Q6
sequenceLength	112
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8975547] UniProt:Q15369-1 ELOC [Homo sapiens] [ReferenceIsoform:8975548] UniProt:Q15369-2 ELOC [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:112422] TCEB1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:180535] ELOC [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q15369 ELOC (89814)