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Details on Person UniProt:Q9EQC4 Elovl4
| Class:Id | ReferenceGeneProduct:89810 |
|---|---|
| _chainChangeLog | chain:1-312 added on Fri February 6 2015 |
| _displayName | UniProt:Q9EQC4 Elovl4 |
| _timestamp | 2025-02-21 19:27:21 |
| chain | chain:1-312 |
| checksum | B049772627D28294 |
| comment | FUNCTION Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.CATALYTIC ACTIVITY a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoACATALYTIC ACTIVITY hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoACATALYTIC ACTIVITY octacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxo-triacontanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY triacontanoyl-CoA + malonyl-CoA + H(+) = 3-oxo-dotriacontanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + malonyl-CoA + H(+) = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoAPATHWAY Lipid metabolism; fatty acid biosynthesis.SUBUNIT Oligomer.SUBCELLULAR LOCATION Expressed in the retina, exclusively in photoreceptor cells and in the brain, skin, testis and lens.DEVELOPMENTAL STAGE Expressed in the ocular tissues of the retina at 10.5 dpc and becomes restricted predominantly to the photoreceptor layer in the mature retina (at protein level). Expressed in the embryo at 7 dpc.DOMAIN The C-terminal di-lysine motif confers endoplasmic reticulum localization.PTM N-glycosylated.DISRUPTION PHENOTYPE Rod or cone-specific conditional knockout of Elovl4 results in a decrease in very long chain (C30-C34) polyunsaturated fatty acids in the retina, but has no effect on photoreceptors survival, phototransduction, synaptic transmission or visual behavior.SIMILARITY Belongs to the ELO family. ELOVL4 subfamily. |
| description | recommendedName: fullName evidence="1"Very long chain fatty acid elongase 4 ecNumber evidence="1 4 5 6 7 8 9"2.3.1.199 alternativeName: fullName evidence="1"3-keto acyl-CoA synthase Elovl4 alternativeName: fullName evidence="1"ELOVL fatty acid elongase 4 shortName evidence="1"ELOVL FA elongase 4 alternativeName: fullName evidence="1"Elongation of very long chain fatty acids protein 4 alternativeName: fullName evidence="1"Very long chain 3-ketoacyl-CoA synthase 4 alternativeName: fullName evidence="1"Very long chain 3-oxoacyl-CoA synthase 4 |
| geneName | Elovl4 |
| identifier | Q9EQC4 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Glycoprotein Lipid biosynthesis Lipid metabolism Membrane Reference proteome Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Elovl4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ELOV4_MOUSE Q8JZV3 |
| sequenceLength | 312 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:548659] Elovl4 [endoplasmic reticulum membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9EQC4 Elovl4 (89810)
