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Details on Person Diagram of RHO GTPase cycle

Class:Id	PathwayDiagram:8980693
_displayName	Diagram of RHO GTPase cycle
_timestamp	2022-06-10 14:56:54
created	[InstanceEdit:8980689] Orlic-Milacic, Marija, 2017-02-28
height	2518
modified	[InstanceEdit:8980805] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:8981642] Orlic-Milacic, Marija, 2017-03-13 [InstanceEdit:9012833] Orlic-Milacic, Marija, 2017-07-19 [InstanceEdit:9012842] Orlic-Milacic, Marija, 2017-07-19 [InstanceEdit:9012985] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9012986] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013001] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013018] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013019] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013020] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013038] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013043] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013051] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013057] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013122] Orlic-Milacic, Marija, 2017-07-23 [InstanceEdit:9013123] Orlic-Milacic, Marija, 2017-07-23 [InstanceEdit:9013128] Orlic-Milacic, Marija, 2017-07-23 [InstanceEdit:9013136] Orlic-Milacic, Marija, 2017-07-23 [InstanceEdit:9013142] Orlic-Milacic, Marija, 2017-07-23 [InstanceEdit:9013188] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9013249] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9013417] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9013468] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9017516] Orlic-Milacic, Marija, 2017-08-21 [InstanceEdit:9017517] Orlic-Milacic, Marija, 2017-08-21 [InstanceEdit:9018857] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9018930] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9019622] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9019623] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020310] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020357] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020358] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020383] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020384] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020408] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020428] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020449] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020458] Orlic-Milacic, Marija, 2017-09-05 [InstanceEdit:9020729] Rothfels, Karen, 2017-09-11 [InstanceEdit:9024519] Orlic-Milacic, Marija, 2017-10-05 [InstanceEdit:9024528] Orlic-Milacic, Marija, 2017-10-05 [InstanceEdit:9024529] Orlic-Milacic, Marija, 2017-10-05 [InstanceEdit:9036003] Orlic-Milacic, Marija, 2018-01-26 [InstanceEdit:9644433] Orlic-Milacic, Marija, 2019-04-12 [InstanceEdit:9644456] Orlic-Milacic, Marija, 2019-04-12 [InstanceEdit:9644582] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9644622] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9644657] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9644685] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9679548] Orlic-Milacic, Marija, 2020-03-24 [InstanceEdit:9679553] Orlic-Milacic, Marija, 2020-03-24 [InstanceEdit:9679585] Orlic-Milacic, Marija, 2020-03-24 [InstanceEdit:9679586] Orlic-Milacic, Marija, 2020-03-24 [InstanceEdit:9681467] Orlic-Milacic, Marija, 2020-04-01 [InstanceEdit:9690071] Orlic-Milacic, Marija, 2020-05-25 [InstanceEdit:9690113] Orlic-Milacic, Marija, 2020-05-26 [InstanceEdit:9690264] Orlic-Milacic, Marija, 2020-05-28 [InstanceEdit:9690483] Orlic-Milacic, Marija, 2020-06-01 [InstanceEdit:9690488] Orlic-Milacic, Marija, 2020-06-01 [InstanceEdit:9690499] Orlic-Milacic, Marija, 2020-06-01 [InstanceEdit:9690523] Orlic-Milacic, Marija, 2020-06-02 [InstanceEdit:9691191] Orlic-Milacic, Marija, 2020-06-09 [InstanceEdit:9691203] Orlic-Milacic, Marija, 2020-06-09 [InstanceEdit:9691552] Orlic-Milacic, Marija, 2020-06-17 [InstanceEdit:9691555] Orlic-Milacic, Marija, 2020-06-17 [InstanceEdit:9691587] Orlic-Milacic, Marija, 2020-06-17 [InstanceEdit:9692451] Orlic-Milacic, Marija, 2020-06-22 [InstanceEdit:9692452] Orlic-Milacic, Marija, 2020-06-22 [InstanceEdit:9692461] Orlic-Milacic, Marija, 2020-06-22 [InstanceEdit:9693139] Orlic-Milacic, Marija, 2020-06-29 [InstanceEdit:9693148] Orlic-Milacic, Marija, 2020-06-29 [InstanceEdit:9693151] Orlic-Milacic, Marija, 2020-06-29 [InstanceEdit:9693165] Orlic-Milacic, Marija, 2020-06-29 [InstanceEdit:9693201] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693202] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693221] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693256] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693262] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693265] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693294] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693354] Orlic-Milacic, Marija, 2020-07-01 [InstanceEdit:9693357] Orlic-Milacic, Marija, 2020-07-01 [InstanceEdit:9693358] Orlic-Milacic, Marija, 2020-07-01 [InstanceEdit:9693526] Orlic-Milacic, Marija, 2020-07-02 [InstanceEdit:9693565] Orlic-Milacic, Marija, 2020-07-02 [InstanceEdit:9693569] Orlic-Milacic, Marija, 2020-07-02 [InstanceEdit:9693616] Orlic-Milacic, Marija, 2020-07-03 [InstanceEdit:9693618] Orlic-Milacic, Marija, 2020-07-03 [InstanceEdit:9693625] Orlic-Milacic, Marija, 2020-07-03 [InstanceEdit:9693642] Orlic-Milacic, Marija, 2020-07-04 [InstanceEdit:9693643] Orlic-Milacic, Marija, 2020-07-04 [InstanceEdit:9693668] Orlic-Milacic, Marija, 2020-07-04 [InstanceEdit:9693704] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693706] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693710] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693754] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693755] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693759] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693769] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693796] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693801] Orlic-Milacic, Marija, 2020-07-06 [InstanceEdit:9693806] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693807] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693819] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693841] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693874] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9693889] Orlic-Milacic, Marija, 2020-07-07 [InstanceEdit:9694045] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9694081] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9694082] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9694106] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9695199] Orlic-Milacic, Marija, 2020-07-11 [InstanceEdit:9695261] Orlic-Milacic, Marija, 2020-07-11 [InstanceEdit:9695504] Orlic-Milacic, Marija, 2020-07-13 [InstanceEdit:9695524] Orlic-Milacic, Marija, 2020-07-13 [InstanceEdit:9695527] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695554] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695565] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9696261] Orlic-Milacic, Marija, 2020-07-20 [InstanceEdit:9696306] Orlic-Milacic, Marija, 2020-07-21 [InstanceEdit:9696336] Orlic-Milacic, Marija, 2020-07-21 [InstanceEdit:9696342] Orlic-Milacic, Marija, 2020-07-21 [InstanceEdit:9696517] Orlic-Milacic, Marija, 2020-07-22 [InstanceEdit:9696522] Orlic-Milacic, Marija, 2020-07-22 [InstanceEdit:9696529] Orlic-Milacic, Marija, 2020-07-22 [InstanceEdit:9696539] Orlic-Milacic, Marija, 2020-07-22 [InstanceEdit:9696543] Orlic-Milacic, Marija, 2020-07-22 [InstanceEdit:9706014] Orlic-Milacic, Marija, 2020-11-04 [InstanceEdit:9706567] Orlic-Milacic, Marija, 2020-11-06 [InstanceEdit:9714358] Orlic-Milacic, Marija, 2021-02-10 [InstanceEdit:9714359] Orlic-Milacic, Marija, 2021-02-10 [InstanceEdit:9714360] Orlic-Milacic, Marija, 2021-02-10 [InstanceEdit:9714449] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9714464] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9714470] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9714472] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9714474] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9714475] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9714526] Orlic-Milacic, Marija, 2021-02-12 [InstanceEdit:9714782] Orlic-Milacic, Marija, 2021-02-14 [InstanceEdit:9714844] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9714863] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9714869] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9714871] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9714872] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9714873] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9714879] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9714886] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715373] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9715375] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9715391] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716666] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716667] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716670] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716671] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716773] Orlic-Milacic, Marija, 2021-02-24 [InstanceEdit:9716804] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9726871] Orlic-Milacic, Marija, 2021-04-13 [InstanceEdit:9727167] Orlic-Milacic, Marija, 2021-04-13 [InstanceEdit:9727168] Orlic-Milacic, Marija, 2021-04-13 [InstanceEdit:9730639] Matthews, Lisa, 2021-05-10 [InstanceEdit:9793327] Orlic-Milacic, Marija, 2022-06-10
representedPathway	[Pathway:9012999] RHO GTPase cycle [Homo sapiens]
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position="1774 659" bounds="1709 639 131 40" textPosition="1711 641"> <Properties> <displayName>RAC2 mitochondrial effectors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="10907" reactomeId="9714510" position="1922 714" bounds="1847 698 150 32" textPosition="1852 695" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RAC2:GTP:RAC2 mitochondrial effectors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="10908" reactomeId="9714761" position="689 621" bounds="627 603 125 36" textPosition="627 603"> <Properties> <displayName>RHOG endoplasmic reticulum effectors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="10911" reactomeId="9714762" position="711 463" bounds="618 444 187 39" textPosition="616 448" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RHOG:GTP:RHOG endoplasmic reticulum effectors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="11119" reactomeId="9013242" position="2065 234" bounds="2031 217 68 35" textPosition="2036 217" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>CDC42 effectors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="11215" reactomeId="9714864" position="878 440" bounds="812 425 133 30" textPosition="813 423"> <Properties> <displayName>CDC42 endoplasmic reticulum effectors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="11221" reactomeId="9714866" position="1006 677" bounds="943 652 127 50" textPosition="943 653" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDC42:GTP:CDC42 endoplasmic reticulum effectors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="11266" reactomeId="9017486" position="3124 1102" bounds="3089 1091 71 22" textPosition="3089 1091" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RHOJ GEFs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="11383" reactomeId="9017506" position="3104 1220" bounds="3058 1209 93 22" textPosition="3058 1209" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RHOJ effectors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="11513" reactomeId="9714689" position="1084 873" bounds="1043 862 82 22" textPosition="1050 863" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="11515" reactomeId="9714686" position="1003 745" bounds="943 723 120 44" textPosition="943 727"> <Properties> <displayName>RAC3 endoplasmic reticulum effectors</displayName> </Properties> 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<displayName>RHOC:GTP:RHOC endoplasmic reticulum effectors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="11954" reactomeId="9014455" position="3053 2088" bounds="3016 2065 75 47" textPosition="3020 2064" /> <org.gk.render.RenderableProtein id="11981" reactomeId="194478" position="2525 185" bounds="2494 174 63 22" textPosition="2494 174"> <Properties> <displayName>ARHGDIA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="11994" reactomeId="194478" position="193 1429" bounds="162 1418 63 22" textPosition="162 1418" /> <org.gk.render.RenderableEntitySet id="12095" reactomeId="9013119" position="193 1580" bounds="155 1569 76 22" textPosition="156 1569" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RHOC GEFs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="12146" reactomeId="9013035" position="183 1079" bounds="146 1068 74 22" textPosition="146 1068" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RHOB GEFs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="12148" reactomeId="113592" position="1489 2382" bounds="1471 2367 37 30" textPosition="1474 2371"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="12149" reactomeId="29370" position="1682 2351" bounds="1660 2338 44 26" textPosition="1666 2340"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="12150" reactomeId="9726855" position="1705 2479" bounds="1668 2462 75 35" textPosition="1670 2462" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y254-RHOU:GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="12151" reactomeId="1810408" position="1586 2480" bounds="1520 2468 132 24" textPosition="1526 2469"> <Properties> <displayName>MyrG-p-Y419-SRC</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.13257575757575757" relativeY="0.0" label="My" trackId="0" reactomeId="1810396" /> <org.gk.render.RenderableFeature relativeX="0.26515151515151514" relativeY="0.0" label="P" trackId="0" reactomeId="1810398" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="12153" reactomeId="9726858" position="942 2134" bounds="880 2122 125 25" textPosition="880 2126" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="692" reactomeId="8980691" points="533 127, 574 130, 613 129" position="574 130" lineWidth="1.0"> <Inputs> <Input id="689" points="503 150" /> <Input id="693" points="468 128" /> </Inputs> <Outputs> <Output id="690" points="627 163" /> <Output id="691" points="654 129" /> </Outputs> <Catalysts> <Catalyst id="7837" points="573 201" /> </Catalysts> <Properties> <displayName>RHOA GEFs activate RHOA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="750" reactomeId="8981637" points="641 277, 575 281, 470 276" position="575 281" lineWidth="1.0"> <Inputs> <Input id="1661" points="653 297" /> <Input id="691" points="688 144" /> </Inputs> <Outputs> <Output id="693" points="432 143" /> <Output id="751" points="456 306" /> </Outputs> <Catalysts> <Catalyst id="792" points="574 327" /> </Catalysts> <Properties> <displayName>RHOA GAPs stimulate RHOA GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="962" reactomeId="9012835" points="352 179, 336 239, 321 304" position="336 239" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="963" points="330 181" /> <Input id="693" points="412 143" /> </Inputs> <Outputs> <Output id="964" /> </Outputs> <Properties> <displayName>GDIs block activation of RHOA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1309" reactomeId="9013009" points="747 134, 768 133, 798 130" position="768 133" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="691" points="731 132" /> <Input id="9525" points="775 192" /> </Inputs> <Outputs> <Output id="1311" /> </Outputs> <Properties> <displayName>RHOA binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1393" reactomeId="9013006" points="692 144, 704 282, 708 359" position="704 282" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="691" /> </Inputs> <Outputs> <Output id="1394" /> </Outputs> <Properties> <displayName>RHOA:GTP translocates to the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1397" reactomeId="9013004" points="792 328, 876 345, 943 362" position="876 345" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1394" points="729 359" /> <Input id="10130" points="810 360" /> </Inputs> <Outputs> <Output id="10132" /> </Outputs> <Properties> <displayName>RHOA binds effectors at the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1594" reactomeId="9013023" points="101 1040, 108 1085, 104 1129" position="108 1085" lineWidth="1.0"> <Inputs> <Input id="1595" points="94 1009" /> <Input id="1599" points="148 1021" /> </Inputs> <Outputs> <Output id="1596" points="95 1162" /> <Output id="1601" points="166 1138" /> </Outputs> <Catalysts> <Catalyst id="12146" points="140 1081" /> </Catalysts> <Properties> <displayName>RHOB GEFs activate RHOB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1681" reactomeId="9013022" points="236 1170, 243 1088, 233 979" position="243 1088" lineWidth="1.0"> <Inputs> <Input id="1596" points="131 1174" /> <Input id="1684" points="259 1185" /> </Inputs> <Outputs> <Output id="1595" points="132 990" /> <Output id="1789" points="273 966" /> </Outputs> <Catalysts> <Catalyst id="1683" points="295 1088" /> </Catalysts> <Properties> <displayName>RHOB GAPs stimulate RHOB GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1785" reactomeId="9013021" points="134 956, 159 952, 208 928" position="159 952" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1595" points="104 981" /> <Input id="1786" points="138 888" /> </Inputs> <Outputs> <Output id="1787" /> </Outputs> <Properties> <displayName>GDIs block activation of RHOB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1849" reactomeId="9013024" points="135 1200, 126 1298, 171 1334" position="126 1298" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1850" points="183 1226" /> <Input id="1596" points="112 1190" /> </Inputs> <Outputs> <Output id="1851" /> </Outputs> <Properties> <displayName>RHOB binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2022" reactomeId="9013109" points="103 1544, 100 1582, 101 1630" position="100 1582" lineWidth="1.0"> <Inputs> <Input id="2023" points="106 1503" /> <Input id="2027" points="147 1537" /> </Inputs> <Outputs> <Output id="2024" points="101 1667" /> <Output id="2029" points="169 1631" /> </Outputs> <Catalysts> <Catalyst id="12095" points="149 1580" /> </Catalysts> <Properties> <displayName>RHOC GEFs activate RHOC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2112" reactomeId="9013111" points="280 1652, 280 1576, 279 1510" position="280 1576" lineWidth="1.0"> <Inputs> <Input id="2113" points="301 1672" /> <Input id="2024" points="141 1675" /> </Inputs> <Outputs> <Output id="2023" points="147 1493" /> <Output id="2116" points="301 1494" /> </Outputs> <Catalysts> <Catalyst id="10156" points="331 1576" /> </Catalysts> <Properties> <displayName>RHOC GAPs stimulate RHOC GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2199" reactomeId="9013108" points="229 1465, 313 1451, 373 1438" position="313 1451" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2023" points="147 1481" /> <Input id="11994" points="204 1443" /> </Inputs> <Outputs> <Output id="2201" /> </Outputs> <Properties> <displayName>GDIs block activation of RHOC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2304" reactomeId="9013110" points="121 1721, 120 1781, 107 1853" position="120 1781" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2024" points="106 1695" /> <Input id="9627" points="173 1732" /> </Inputs> <Outputs> <Output id="2306" /> </Outputs> <Properties> <displayName>RHOC binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2709" reactomeId="9013143" points="1074 130, 1114 124, 1150 125" position="1114 124" lineWidth="1.0"> <Inputs> <Input id="2710" points="1036 128" /> <Input id="2714" points="1058 153" /> </Inputs> <Outputs> <Output id="7162" points="1226 135" /> <Output id="2716" points="1176 158" /> </Outputs> <Catalysts> <Catalyst id="7340" points="1113 184" /> </Catalysts> <Properties> <displayName>RAC1 GEFs activate RAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2717" reactomeId="9013144" points="1178 250, 1117 240, 1027 238" position="1117 240" lineWidth="1.0"> <Inputs> <Input id="7162" points="1254 154" /> <Input id="7163" points="1200 265" /> </Inputs> <Outputs> <Output id="2710" points="1000 141" /> <Output id="2721" points="985 263" /> </Outputs> <Catalysts> <Catalyst id="2719" points="1114 277" /> </Catalysts> <Properties> <displayName>RAC1 GAPs stimulate RAC1 GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2722" reactomeId="9013147" points="962 196, 932 251, 904 285" position="932 251" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2710" points="992 141" /> <Input id="963" points="280 166, 281 65, 943 67" /> </Inputs> <Outputs> <Output id="2724" /> </Outputs> <Properties> <displayName>RAC1 GDIs block activation of RAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2725" reactomeId="9013145" points="1355 167, 1381 126, 1418 127" position="1381 126" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7162" points="1301 150" /> <Input id="2726" points="1333 209" /> </Inputs> <Outputs> <Output id="2727" /> </Outputs> <Properties> <displayName>RAC1 binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2941" reactomeId="9013159" points="1712 131, 1752 131, 1802 129" position="1752 131" lineWidth="1.0"> <Inputs> <Input id="2942" points="1660 128" /> <Input id="2946" points="1670 163" /> </Inputs> <Outputs> <Output id="2943" points="1847 128" /> <Output id="2948" points="1824 170" /> </Outputs> <Catalysts> <Catalyst id="7513" points="1746 192" /> </Catalysts> <Properties> <displayName>CDC42 GEFs activate CDC42</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2951" reactomeId="9013161" points="1861 254, 1747 272, 1626 263" position="1747 272" lineWidth="1.0"> <Inputs> <Input id="2943" points="1889 143" /> <Input id="2952" points="1855 317" /> </Inputs> <Outputs> <Output id="2942" points="1618 143" /> <Output id="2950" points="1596 315" /> </Outputs> <Catalysts> <Catalyst id="2953" points="1746 338" /> </Catalysts> <Properties> <displayName>CDC42 GAPs stimulate CDC42 GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2954" reactomeId="9013158" points="1518 239, 1508 263, 1510 301" position="1508 263" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2955" points="1471 212" /> <Input id="2942" points="1606 143" /> </Inputs> <Outputs> <Output id="2956" /> </Outputs> <Properties> <displayName>CDC42 GDIs block activation of CDC42</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2957" reactomeId="9013157" points="1991 203, 1993 239, 1995 329" position="1993 239" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2943" points="1907 143" /> <Input id="11119" points="2025 219" /> </Inputs> <Outputs> <Output id="2959" /> </Outputs> <Properties> <displayName>CDC42 binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3342" reactomeId="9013435" points="2222 138, 2259 137, 2291 135" position="2259 137" lineWidth="1.0"> <Inputs> <Input id="3343" points="2143 144" /> <Input id="3347" points="2199 184" /> </Inputs> <Outputs> <Output id="3344" points="2324 132" /> <Output id="3349" points="2308 183" /> </Outputs> <Catalysts> <Catalyst id="3343" points="2132 133, 2211 109" /> </Catalysts> <Properties> <displayName>RHOD auto-activates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3352" reactomeId="9013437" points="2351 254, 2268 284, 2171 263" position="2268 284" lineWidth="1.0"> <Inputs> <Input id="3344" points="2362 145" /> <Input id="3353" points="2350 315" /> </Inputs> <Outputs> <Output id="3343" points="2107 161" /> <Output id="3351" points="2145 333" /> </Outputs> <Catalysts> <Catalyst id="3354" points="2268 335" /> </Catalysts> <Properties> <displayName>RHOD GAPs stimulate RHOD GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3358" reactomeId="9013452" points="2366 145, 2417 340, 2461 534" position="2417 340" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3344" /> </Inputs> <Outputs> <Output id="3359" /> </Outputs> <Properties> <displayName>RHOD:GTP translocates to the endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3362" reactomeId="9013438" points="2492 598, 2551 598, 2558 631" position="2551 598" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8314" points="2412 570" /> <Input id="3359" points="2470 562" /> </Inputs> <Outputs> <Output id="3364" /> </Outputs> <Properties> <displayName>RHOD binds effectors at the endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3546" reactomeId="9017491" points="3210 1070, 3210 1099, 3210 1144" position="3210 1099" lineWidth="1.0"> <Inputs> <Input id="3547" points="3210 1032" /> <Input id="3551" points="3167 1055" /> </Inputs> <Outputs> <Output id="3548" points="3207 1186" /> <Output id="3553" points="3171 1149" /> </Outputs> <Catalysts> <Catalyst id="11266" points="3166 1100" /> </Catalysts> <Properties> <displayName>RHOJ GEFs activate RHOJ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3554" reactomeId="9017488" points="3047 1164, 3045 1097, 3047 1034" position="3045 1097" lineWidth="1.0"> <Inputs> <Input id="3548" points="3168 1192" /> <Input id="3555" points="3012 1180" /> </Inputs> <Outputs> <Output id="3547" points="3170 1020" /> <Output id="3558" points="3016 1024" /> </Outputs> <Catalysts> <Catalyst id="8607" points="2976 1096" /> </Catalysts> <Properties> <displayName>RHOJ GAPs stimulate RHOJ GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3604" reactomeId="9017507" points="3200 1251, 3204 1288, 3202 1322" position="3204 1288" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3548" points="3205 1216" /> <Input id="11383" points="3138 1237" /> </Inputs> <Outputs> <Output id="3606" /> </Outputs> <Properties> <displayName>RHOJ binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4723" reactomeId="9018747" points="3207 1486, 3208 1532, 3207 1578" position="3208 1532" lineWidth="1.0"> <Inputs> <Input id="4724" points="3205 1417" /> <Input id="4728" points="3166 1479" /> </Inputs> <Outputs> <Output id="4725" points="3207 1621" /> <Output id="4730" points="3156 1587" /> </Outputs> <Catalysts> <Catalyst id="8692" points="3133 1528" /> </Catalysts> <Properties> <displayName>RHOQ GEFs activate RHOQ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4751" reactomeId="9018745" points="3029 1626, 3023 1536, 3025 1425" position="3023 1536" lineWidth="1.0"> <Inputs> <Input id="4752" points="2959 1623" /> <Input id="4725" points="3169 1633" /> </Inputs> <Outputs> <Output id="4724" points="3166 1407" /> <Output id="4755" points="2978 1409" /> </Outputs> <Catalysts> <Catalyst id="8726" points="2964 1534" /> </Catalysts> <Properties> <displayName>RHOQ GAPs stimulate RHOQ GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4759" reactomeId="9018746" points="3186 1718, 3188 1762, 3214 1820" position="3188 1762" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4725" points="3205 1649" /> <Input id="8802" points="3121 1680" /> </Inputs> <Outputs> <Output id="4761" /> </Outputs> <Properties> <displayName>RHOQ binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4762" reactomeId="9018836" points="3169 1636, 2839 1648, 2750 1570" position="2839 1648" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="4725" /> </Inputs> <Outputs> <Output id="4763" /> </Outputs> <Properties> <displayName>RHOQ translocates to the Golgi-associated vesicle membranes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4765" reactomeId="5627072" points="2646 1514, 2686 1496, 2716 1470" position="2686 1496" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4766" points="2623 1477" /> <Input id="4763" points="2713 1542" /> </Inputs> <Outputs> <Output id="4767" /> </Outputs> <Properties> <displayName>RHOQ binds GOPC:CFTR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4894" reactomeId="9018756" points="3227 1997, 3230 2037, 3231 2093" position="3230 2037" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8933" points="3225 1965" /> <Input id="4899" points="3187 2001" /> </Inputs> <Outputs> <Output id="4896" /> </Outputs> <Properties> <displayName>RHOH binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4930" reactomeId="9018758" points="3234 2170, 3233 2212, 3233 2258" position="3233 2212" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4931" points="3196 2166" /> <Input id="4896" points="3232 2121" /> </Inputs> <Outputs> <Output id="4932" /> </Outputs> <Properties> <displayName>RHOH binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5181" reactomeId="9018768" points="1339 2475, 1293 2474, 1246 2475" position="1293 2474" lineWidth="1.0"> <Inputs> <Input id="5182" points="1421 2476" /> <Input id="5186" points="1353 2454" /> </Inputs> <Outputs> <Output id="5183" points="1200 2475" /> <Output id="5188" points="1220 2439" /> </Outputs> <Catalysts> <Catalyst id="5182" points="1421 2484, 1307 2510" /> </Catalysts> <Properties> <displayName>RHOU auto-activates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5239" reactomeId="9018766" points="1112 2412, 1079 2436, 1058 2463" position="1079 2436" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5240" points="1099 2383" /> <Input id="5183" points="1152 2462" /> </Inputs> <Outputs> <Output id="5241" /> </Outputs> <Properties> <displayName>RHOU binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5284" reactomeId="9014296" points="2694 133, 2726 136, 2757 134" position="2726 136" lineWidth="1.0"> <Inputs> <Input id="5285" points="2657 128" /> <Input id="5289" points="2672 166" /> </Inputs> <Outputs> <Output id="5286" points="2785 133" /> <Output id="5291" points="2776 165" /> </Outputs> <Catalysts> <Catalyst id="7672" points="2726 221" /> </Catalysts> <Properties> <displayName>RAC2 GEFs activate RAC2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5292" reactomeId="9014295" points="2822 267, 2735 286, 2637 281" position="2735 286" lineWidth="1.0"> <Inputs> <Input id="5293" points="2819 311" /> <Input id="5286" points="2822 146" /> </Inputs> <Outputs> <Output id="5285" points="2620 138" /> <Output id="5296" points="2611 306" /> </Outputs> <Catalysts> <Catalyst id="8019" points="2734 355" /> </Catalysts> <Properties> <displayName>RAC2 GAPs stimulate RAC2 GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5297" reactomeId="9014293" points="2592 178, 2572 219, 2574 241" position="2572 219" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11981" points="2560 181" /> <Input id="5285" points="2613 138" /> </Inputs> <Outputs> <Output id="5299" /> </Outputs> <Properties> <displayName>RAC2 GDIs block activation of RAC2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5300" reactomeId="9014294" points="2971 193, 3001 191, 3052 153" position="3001 191" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5286" points="2848 146" /> <Input id="10625" points="2955 218" /> </Inputs> <Outputs> <Output id="5302" /> </Outputs> <Properties> <displayName>RAC2 binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5303" reactomeId="9014420" points="2826 146, 2906 334, 2814 482" position="2906 334" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5286" /> </Inputs> <Outputs> <Output id="5304" /> </Outputs> <Properties> <displayName>RAC2 translocates to the phagocytic vesicle membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5306" reactomeId="9014424" points="2895 522, 2917 535, 2942 565" position="2917 535" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5307" points="2908 501" /> <Input id="5304" points="2846 506" /> </Inputs> <Outputs> <Output id="5308" /> </Outputs> <Properties> <displayName>RAC2 binds effectors at the phagocytic vesicle membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5329" reactomeId="9014433" points="97 497, 98 546, 100 583" position="98 546" lineWidth="1.0"> <Inputs> <Input id="5330" points="100 466" /> <Input id="5354" points="147 491" /> </Inputs> <Outputs> <Output id="5331" points="95 615" /> <Output id="5356" points="142 590" /> </Outputs> <Catalysts> <Catalyst id="5332" points="162 541" /> </Catalysts> <Properties> <displayName>RHOG GEFs activate RHOG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5357" reactomeId="9014434" points="264 621, 267 540, 280 465" position="267 540" lineWidth="1.0"> <Inputs> <Input id="5331" points="133 627" /> <Input id="5358" points="302 645" /> </Inputs> <Outputs> <Output id="751" points="437 336" /> <Output id="5330" points="142 454" /> </Outputs> <Catalysts> <Catalyst id="5359" points="324 534" /> </Catalysts> <Properties> <displayName>RHOG GAPs stimulate RHOG GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5360" reactomeId="9014456" points="140 404, 167 404, 190 403" position="167 404" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5361" points="149 374" /> <Input id="5330" points="110 438" /> </Inputs> <Outputs> <Output id="5362" /> </Outputs> <Properties> <displayName>GDIs block activation of RHOG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5363" reactomeId="9014449" points="154 677, 142 707, 120 759" position="142 707" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5331" points="107 643" /> <Input id="5364" points="200 690" /> </Inputs> <Outputs> <Output id="5365" /> </Outputs> <Properties> <displayName>RHOG binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5366" reactomeId="9014454" points="133 637, 397 704, 648 577" position="397 704" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5331" /> </Inputs> <Outputs> <Output id="5367" /> </Outputs> <Properties> <displayName>RHOG translocates to the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5368" reactomeId="9014467" points="758 570, 769 539, 725 486" position="769 539" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5367" points="709 565" /> <Input id="10908" points="713 597" /> </Inputs> <Outputs> <Output id="10911" /> </Outputs> <Properties> <displayName>RHOG binds effectors at the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5617" reactomeId="9018774" points="506 2008, 539 2008, 590 2009" position="539 2008" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="8844" points="476 2006" /> <Input id="5622" points="497 1964" /> </Inputs> <Outputs> <Output id="5619" /> </Outputs> <Properties> <displayName>RHOBTB1 binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5633" reactomeId="9018778" points="713 2007, 753 2008, 827 2009" position="753 2008" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5634" points="697 1946" /> <Input id="5619" points="689 2008" /> </Inputs> <Outputs> <Output id="5635" /> </Outputs> <Properties> <displayName>RHOBTB1 binds interacting proteins at the endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5879" reactomeId="9018785" points="506 2260, 561 2259, 606 2256" position="561 2259" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8849" points="469 2256" /> <Input id="5886" points="499 2278" /> </Inputs> <Outputs> <Output id="5881" /> </Outputs> <Catalysts> <Catalyst id="8889" points="562 2316" /> </Catalysts> <Properties> <displayName>RHOBTB2 binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5935" reactomeId="9018787" points="734 2255, 764 2253, 803 2255" position="764 2253" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5936" points="733 2297" /> <Input id="5881" points="706 2254" /> </Inputs> <Outputs> <Output id="5937" /> </Outputs> <Properties> <displayName>RHOBTB2 binds interacting proteins at the endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6321" reactomeId="9018798" points="656 2461, 697 2462, 727 2462" position="697 2462" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="6322" points="605 2471" /> <Input id="6326" points="622 2418" /> </Inputs> <Outputs> <Output id="6323" points="761 2471" /> <Output id="6328" points="755 2430" /> </Outputs> <Properties> <displayName>RHOV binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6378" reactomeId="9018794" points="850 2429, 875 2427, 906 2456" position="875 2427" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6323" points="810 2466" /> <Input id="6379" points="862 2372" /> </Inputs> <Outputs> <Output id="6380" /> </Outputs> <Properties> <displayName>RHOV binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6583" reactomeId="9018804" points="3232 350, 3234 406, 3232 464" position="3234 406" lineWidth="1.0"> <Inputs> <Input id="6584" points="3230 307" /> <Input id="6589" points="3186 340" /> </Inputs> <Outputs> <Output id="6610" points="3231 552" /> <Output id="6587" points="3193 492" /> </Outputs> <Catalysts> <Catalyst id="7706" points="3195 407" /> </Catalysts> <Properties> <displayName>RAC3 GEFs activate RAC3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6611" reactomeId="9018806" points="3076 542, 3071 414, 3071 321" position="3071 414" lineWidth="1.0"> <Inputs> <Input id="6612" points="3064 564" /> <Input id="6610" points="3194 560" /> </Inputs> <Outputs> <Output id="6584" points="3192 298" /> <Output id="6615" points="3039 319" /> </Outputs> <Catalysts> <Catalyst id="8211" points="3034 414" /> </Catalysts> <Properties> <displayName>RAC3 GAPs stimulate RAC3 GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6616" reactomeId="9018807" points="3175 242, 3143 272, 3110 263" position="3143 272" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6584" points="3217 278" /> <Input id="8228" points="3156 206" /> </Inputs> <Outputs> <Output id="6618" /> </Outputs> <Properties> <displayName>RAC3 GDIs block activation of RAC3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6619" reactomeId="9018808" points="3168 584, 3194 613, 3225 644" position="3194 613" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6610" points="3194 575" /> <Input id="8240" points="3122 613" /> </Inputs> <Outputs> <Output id="6621" /> </Outputs> <Properties> <displayName>RAC3 binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7920" reactomeId="9690494" points="131 1184, 479 1272, 2288 696" position="479 1272" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1596" /> </Inputs> <Outputs> <Output id="7921" /> </Outputs> <Properties> <displayName>RHOB translocates to the endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7958" reactomeId="9690493" points="2317 749, 2371 775, 2435 757" position="2371 775" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7959" points="2274 788" /> <Input id="7921" points="2319 696" /> </Inputs> <Outputs> <Output id="7961" /> </Outputs> <Properties> <displayName>RHOB binds effectors on endosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7962" reactomeId="9691168" points="1262 154, 1253 394, 1055 472" position="1253 394" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="7162" /> </Inputs> <Outputs> <Output id="7963" /> </Outputs> <Properties> <displayName>RAC1 translocates to the endoplasmic reticulum membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7964" reactomeId="9691174" points="945 482, 942 522, 981 528" position="942 522" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7963" points="992 484" /> <Input id="10404" points="992 454" /> </Inputs> <Outputs> <Output id="10407" /> </Outputs> <Properties> <displayName>RAC1 binds effectors at the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8325" reactomeId="9693198" points="2448 230, 2468 199, 2472 155" position="2468 199" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3363" points="2582 355" /> <Input id="3344" points="2373 145" /> </Inputs> <Outputs> <Output id="8326" /> </Outputs> <Properties> <displayName>RHOD binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8353" reactomeId="9693207" points="2365 145, 2394 354, 2179 571" position="2394 354" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="3344" /> </Inputs> <Outputs> <Output id="8354" /> </Outputs> <Properties> <displayName>RHOD translocates to the mitochondrial outer membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8362" reactomeId="9693214" points="1924 602, 1944 580, 1986 566" position="1944 580" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8354" points="2129 587" /> <Input id="8363" points="1872 592" /> </Inputs> <Outputs> <Output id="8366" /> </Outputs> <Properties> <displayName>RHOD binds effectors at the mitochondrial outer membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8369" reactomeId="9692800" points="1892 143, 1905 381, 1060 582" position="1905 381" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="2943" /> </Inputs> <Outputs> <Output id="8370" /> </Outputs> <Properties> <displayName>CDC42 translocates to the endoplasmic reticulum membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8371" reactomeId="9692809" points="893 523, 901 585, 977 649" position="901 585" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11215" points="880 461" /> <Input id="8370" points="996 578" /> </Inputs> <Outputs> <Output id="11221" /> </Outputs> <Properties> <displayName>CDC42 binds effectors at the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8373" reactomeId="9693243" points="2371 145, 2594 484, 2654 832" position="2594 484" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="3344" /> </Inputs> <Outputs> <Output id="8374" /> </Outputs> <Properties> <displayName>RHOD translocates to the Golgi membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8395" reactomeId="9693250" points="2569 892, 2552 922, 2542 969" position="2552 922" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8374" points="2635 860" /> <Input id="8396" points="2533 875" /> </Inputs> <Outputs> <Output id="8397" /> </Outputs> <Properties> <displayName>RHOD binds effectors at the Golgi membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8507" reactomeId="9693111" points="3237 749, 3235 780, 3242 816" position="3235 780" lineWidth="1.0"> <Inputs> <Input id="8508" points="3237 725" /> <Input id="8511" points="3181 744" /> </Inputs> <Outputs> <Output id="8509" points="3235 841" /> <Output id="8513" points="3178 812" /> </Outputs> <Catalysts> <Catalyst id="8508" points="3248 725, 3275 750" /> </Catalysts> <Properties> <displayName>RHOF auto-activates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8516" reactomeId="9693282" points="3101 828, 3103 777, 3101 710" position="3103 777" lineWidth="1.0"> <Inputs> <Input id="8509" points="3194 847" /> <Input id="8517" points="3077 837" /> </Inputs> <Outputs> <Output id="8508" points="3197 710" /> <Output id="8529" points="3074 703" /> </Outputs> <Catalysts> <Catalyst id="8518" points="3068 777" /> </Catalysts> <Properties> <displayName>RHOF GAPs stimulate RHOF GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8530" reactomeId="9693125" points="3135 865, 3173 890, 3215 922" position="3173 890" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8531" points="3052 883" /> <Input id="8509" points="3194 858" /> </Inputs> <Outputs> <Output id="8543" /> </Outputs> <Properties> <displayName>RHOF binds effectors at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8946" reactomeId="9018754" points="3160 2061, 3106 2030, 3054 2011" position="3106 2030" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4896" points="3214 2093" /> <Input id="11954" points="3097 2078" /> </Inputs> <Outputs> <Output id="4929" /> </Outputs> <Properties> <displayName>GDIs bind RHOH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9800" reactomeId="9696274" points="1837 2475, 1867 2477, 1907 2476" position="1867 2477" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9801" points="1815 2477" /> <Input id="9804" points="1826 2449" /> </Inputs> <Outputs> <Output id="9802" /> </Outputs> <Properties> <displayName>RND1 binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9807" reactomeId="9696271" points="2014 2479, 2038 2477, 2085 2478" position="2038 2477" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9802" points="1986 2477" /> <Input id="10037" points="1985 2434" /> </Inputs> <Outputs> <Output id="9809" /> </Outputs> <Properties> <displayName>RND1 binds effectors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9812" reactomeId="9696275" points="2299 2478, 2327 2479, 2365 2479" position="2327 2479" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9813" points="2271 2478" /> <Input id="9816" points="2284 2441" /> </Inputs> <Outputs> <Output id="9814" /> </Outputs> <Properties> <displayName>RND2 binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9817" reactomeId="9696266" points="2481 2475, 2514 2477, 2551 2477" position="2514 2477" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9814" points="2448 2476" /> <Input id="10038" points="2470 2441" /> </Inputs> <Outputs> <Output id="9819" /> </Outputs> <Properties> <displayName>RND2 binds effectors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9822" reactomeId="9696267" points="2781 2478, 2814 2478, 2860 2477" position="2814 2478" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9823" points="2748 2478" /> <Input id="9826" points="2769 2443" /> </Inputs> <Outputs> <Output id="9824" /> </Outputs> <Properties> <displayName>RND3 binds GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9827" reactomeId="9696268" points="2984 2479, 3035 2476, 3078 2476" position="3035 2476" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9824" points="2943 2477" /> <Input id="10039" points="2967 2427" /> </Inputs> <Outputs> <Output id="9829" /> </Outputs> <Properties> <displayName>RND3 binds effectors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10883" reactomeId="9714483" points="2824 146, 2877 334, 2686 570, 2814 1118, 1133 1128, 974 883" position="2877 334" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5286" /> </Inputs> <Outputs> <Output id="10884" /> </Outputs> <Properties> <displayName>RAC2 translocates to the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10885" reactomeId="9714481" points="857 733, 833 755, 787 775" position="833 755" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="10886" points="757 709" /> <Input id="10884" points="958 855" /> </Inputs> <Outputs> <Output id="10888" /> </Outputs> <Properties> <displayName>RAC2 binds effectors at the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10896" reactomeId="9714480" points="2823 146, 2854 337, 2636 528, 2610 720, 2196 630" position="2854 337" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="5286" /> </Inputs> <Outputs> <Output id="10897" /> </Outputs> <Properties> <displayName>RAC2 translocates to the mitochondrial membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10905" reactomeId="9714477" points="2063 655, 2038 683, 1981 695" position="2038 683" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="10897" points="2125 637" /> <Input id="10906" points="1846 658" /> </Inputs> <Outputs> <Output id="10907" /> </Outputs> <Properties> <displayName>RAC2 binds effectors at the mitochondrial outer membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="11218" points="951 430, 951 430" position="951 430" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="11215" /> </Inputs> <Outputs> <Output id="10404" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="11512" reactomeId="9714694" points="3194 574, 2840 665, 2847 1059, 1753 1053, 1124 887" position="2847 1059" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="6610" /> </Inputs> <Outputs> <Output id="11513" /> </Outputs> <Properties> <displayName>RAC3 translocates to the endoplasmic reticulum membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11514" reactomeId="9714691" points="1085 794, 1123 790, 1189 731" position="1123 790" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11513" points="1084 859" /> <Input id="11515" points="1039 773" /> </Inputs> <Outputs> <Output id="11520" /> </Outputs> <Properties> <displayName>RAC3 binds ER effectors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11539" reactomeId="9714363" points="141 1687, 407 1738, 640 1460, 686 955" position="407 1738" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="2024" /> </Inputs> <Outputs> <Output id="11540" /> </Outputs> <Properties> <displayName>RHOC translocates to the endoplasmic reticulum membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11541" reactomeId="9714361" points="796 924, 824 927, 863 938" position="824 927" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11540" points="729 934" /> <Input id="11542" points="758 902" /> </Inputs> <Outputs> <Output id="11548" /> </Outputs> <Properties> <displayName>RHOC activates endoplasmic reticulum effectors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12147" reactomeId="9726848" points="1505 2448, 1582 2414, 1619 2416" position="1582 2414" lineWidth="1.0"> <Inputs> <Input id="12148" points="1492 2400" /> <Input id="5182" points="1477 2463" /> </Inputs> <Outputs> <Output id="12149" points="1669 2367" /> <Output id="12150" points="1681 2459" /> </Outputs> <Catalysts> <Catalyst id="12151" points="1585 2465" /> </Catalysts> <Properties> <displayName>SRC phosphorylates RHOU</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12152" reactomeId="9726862" points="1706 2459, 1722 2216, 1008 2140" position="1722 2216" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="12150" /> </Inputs> <Outputs> <Output id="12153" /> </Outputs> <Properties> <displayName>Phosphorylated RHOU translocates to the endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of RHO GTPase cycle (8980693)