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Details on Person p-polyUbK48-TRAF3IP2 degradation by SCF complex

Class:Id	BlackBoxEvent:8980487
_displayName	p-polyUbK48-TRAF3IP2 degradation by SCF complex
_doRelease	FALSE
_timestamp	2017-08-14 13:48:02
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8980488] Duenas, Corina, 2017-02-27
input	[Complex:8980431] IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:K48polyUb,p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8979550] Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1
modified	[InstanceEdit:8983619] Duenas, Corina, 2017-03-27 [InstanceEdit:9015115] Duenas, Corina, 2017-08-08 [InstanceEdit:9016491] Duenas, Corina, 2017-08-14
name	p-polyUbK48-TRAF3IP2 degradation by SCF complex p-polyUbK48-ACT1 degradation by SCF complex ACT1 complex degradation
output	[Complex:8983581] IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8980457] SCF-beta-TrCp1,2 K48 polyubiquitinates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [Homo sapiens] [BlackBoxEvent:8980376] SCF-beta-TrCp1,2 binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8980490] R-HSA-8980487.1
summation	[Summation:8980489] Interleukin-17 (IL17) stimulates Adapter protein CIKS (TRAF3...
(hasEvent)	[Pathway:448424] Interleukin-17 signaling [Homo sapiens]
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No pathways have been reviewed or authored by p-polyUbK48-TRAF3IP2 degradation by SCF complex (8980487)