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Details on Person SCF-beta-TrCp1,2 K48 polyubiquitinates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)

Class:Id	BlackBoxEvent:8980457
_displayName	SCF-beta-TrCp1,2 K48 polyubiquitinates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)
_doRelease	FALSE
_timestamp	2017-08-14 13:46:02
catalystActivity	[CatalystActivity:8980283] ubiquitin protein ligase activity of IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S,3Hyp-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643213] ubiquitin protein ligase activity of IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S,3Hyp-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [plasma membrane] Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8980456] Duenas, Corina, 2017-02-27
input	[Complex:8980278] IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S,3Hyp-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8979550] Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1
modified	[InstanceEdit:8983529] Jupe, Steve, 2017-03-24 [InstanceEdit:8983963] Duenas, Corina, 2017-03-31 [InstanceEdit:9015115] Duenas, Corina, 2017-08-08 [InstanceEdit:9016491] Duenas, Corina, 2017-08-14 [InstanceEdit:9643047] Wu, G, 2019-04-04
name	SCF-beta-TrCp1,2 K48 polyubiquitinates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) TRAF3IP2 is K48 polyubiquitinated by SFC complex ACT1 is K48 polyubiquitinated by SFC complex
output	[Complex:8980431] IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:K48polyUb,p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8980376] SCF-beta-TrCp1,2 binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2 [Homo sapiens] [Reaction:8980328] IKBKE phosphorylates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8980458] R-HSA-8980457.1
summation	[Summation:8980435] The SCFbeta-TrCP complex, which consists of S-phase kinase-a...
(hasEvent)	[Pathway:448424] Interleukin-17 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8980487] p-polyUbK48-TRAF3IP2 degradation by SCF complex [Homo sapiens]
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No pathways have been reviewed or authored by SCF-beta-TrCp1,2 K48 polyubiquitinates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) (8980457)