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Details on Person TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6

Class:Id	BlackBoxEvent:8980352
_displayName	TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6
_doRelease	FALSE
_timestamp	2017-08-14 13:46:33
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8980350] Duenas, Corina, 2017-02-27
inferredFrom	[BlackBoxEvent:8983936] Tak1:Tab2:Tab3 complex binds K63-polyUb-Traf6 [Mus musculus]
input	[Complex:8980241] IL17A dimer,IL17F dimer,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6:UBE2N:UBE2V1 [plasma membrane] [Homo sapiens] [Complex:8979873] MAP3K7:TAB2:TAB3 [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:8983953] Duenas, Corina, 2017-03-31 [InstanceEdit:8983971] Duenas, Corina, 2017-03-31 [InstanceEdit:9015115] Duenas, Corina, 2017-08-08 [InstanceEdit:9016491] Duenas, Corina, 2017-08-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04
name	TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6 Activation of TAK1:TAB2:TAB3 complex
output	[Complex:8980244] IL17A dimer,L17F dimer,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6:UBE2N:UBE2V1:MAP3K7:TAB2:TAB3 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8980347] miRNA-23b upregulated after NFKB activation by IL17-IL17R interaction [Homo sapiens] [Pathway:8980345] NFKbeta canonical pathway [Homo sapiens] [Reaction:8980295] Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction [Homo sapiens] [Reaction:8980293] TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex [Homo sapiens]
regulatedBy	[NegativeRegulation:8980346] Negative regulation by 'miR-23b [cytosol]'
regulationReference	[RegulationReference:9641478] Negative regulation by 'miR-23b [cytosol]' The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8980357] R-HSA-8980352.1
summation	[Summation:8980103] Inferred from mouse: Mitogen-activated protein kinase ki...
(hasEvent)	[Pathway:448424] Interleukin-17 signaling [Homo sapiens]
(precedingEvent)	[Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 [Homo sapiens] [Pathway:450302] activated TAK1 mediates p38 MAPK activation [Homo sapiens] [Pathway:5684996] MAPK1/MAPK3 signaling [Homo sapiens] [Pathway:8980345] NFKbeta canonical pathway [Homo sapiens]
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No pathways have been reviewed or authored by TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6 (8980352)